1-Bromo-3-cyclopropylmethoxy-4-difluoromethoxybenzene

Base Information

• Chemical Name: 1-Bromo-3-cyclopropylmethoxy-4-difluoromethoxybenzene
• CAS No.: 680184-55-8
• Molecular Formula: C11H11BrF2O2
• Molecular Weight: 293.108
• DSSTox Substance ID: DTXSID20434282
• Wikidata: Q82248643
• Mol file: 680184-55-8.mol

Synonyms:1-bromo-3-cyclopropylmethoxy-4-difluoromethoxybenzene;680184-55-8;SCHEMBL131011;DTXSID20434282;4-bromo-2-cyclopropylmethoxy-1-difluoromethoxybenzene

Chemical Property of 1-Bromo-3-cyclopropylmethoxy-4-difluoromethoxybenzene

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 291.99105
• Heavy Atom Count: 16
• Complexity: 224

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1COC2=C(C=CC(=C2)Br)OC(F)F

Technology Process of 1-Bromo-3-cyclopropylmethoxy-4-difluoromethoxybenzene

There total 2 articles about 1-Bromo-3-cyclopropylmethoxy-4-difluoromethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

4-bromo-2-cyclopropylmethoxyphenol (680184-56-9) + 1,10-phenanthroline trifluoroacetic acid cuprous (I) → 4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene (680184-55-8)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 75 ℃; for 4h;

DOI:10.1002/chem.201504306

Reference yield:

4-bromo-2-cyclopropylmethoxyphenol (680184-56-9) → 4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene (680184-55-8)

Guidance literature:

With Chlorodifluoromethane; tetrabutylammomium bromide; at 65 - 80 ℃; for 1.16667h;

Reference yield: 100.0%

4-bromo-2-(cyclopropylmethoxy)-1-(difluoromethoxy)benzene (680184-55-8) → 5-bromo-2-difluoromethoxyphenol (944334-04-7)

Guidance literature:

With hydrogenchloride; methanol; water; for 5h; Heating / reflux;

upstream raw materials:

4-bromo-2-cyclopropylmethoxyphenol

Downstream raw materials:

5-bromo-2-difluoromethoxyphenol

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

4-bromo-1-difluoromethoxy-2-(1,1-dimethyl-2-propynyloxy)benzene

4-bromo-2-(1-cyclopropyl-2-propynyloxy)-1-difluoromethoxybenzene