8-Benzyloxyquinoline

Base Information

• Chemical Name: 8-Benzyloxyquinoline
• CAS No.: 84165-42-4
• Molecular Formula: C16H13 N O
• Molecular Weight: 235.285
• Hs Code.: 2933499090
• Mol file: 84165-42-4.mol

Synonyms:8-(Benzyloxy)quinoline;NSC 646915

Chemical Property of 8-Benzyloxyquinoline

Chemical Property:

• Vapor Pressure: 3.51E-06mmHg at 25°C
• Melting Point: 118 °C
• Boiling Point: 397.9°C at 760 mmHg
• PKA: 3.31±0.17(Predicted)
• Flash Point: 144.3°C
• PSA: 22.12000
• Density: 1.167g/cm³
• LogP: 3.81380

Purity/Quality:

8-BENZYLOXYQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Benzyloxyquinoline

There total 19 articles about 8-Benzyloxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

8-quinolinol (148-24-3,24804-14-6) + benzyl chloride (100-44-7) → 8-(benzyloxy)quinoline (84165-42-4)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; water; at 25 ℃; for 4h;

DOI:10.1055/s-1982-29976

Reference yield: 90.0%

8-quinolinol (148-24-3,24804-14-6) + benzyl alcohol (100-51-6,185532-71-2) → 8-(benzyloxy)quinoline (84165-42-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 - 30 ℃; regioselective reaction; Inert atmosphere;

DOI:10.3987/COM-17-13710

Reference yield: 90.0%

N-methylaniline (100-61-8) + 8-(benzyloxy)-5-bromoquinoline (202259-06-1) → 8-(benzyloxy)quinoline (84165-42-4) + 5-(N-methylanilino)-8-benzyloxyquinoline

Guidance literature:

With di-tert-butylneopentylphosphine tetrafluoroborate; palladium diacetate; sodium t-butanolate; In toluene; at 110 - 120 ℃; for 0.5h; Reagent/catalyst; Inert atmosphere;

DOI:10.1007/s12039-015-0960-5

upstream raw materials:

8-quinolinol

benzyl chloride

pyrrolidine

8-(benzyloxy)-5-bromoquinoline

Downstream raw materials:

8-(benzyloxy)-5-bromoquinoline