Technology Process of 1,5-Benzoxazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-phenyl-,
(2R,3R)-
There total 1 articles about 1,5-Benzoxazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-phenyl-,
(2R,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
scandium tris(trifluoromethanesulfonate);
In
acetonitrile;
at 20 ℃;
for 25h;
Heating / reflux;
- Guidance literature:
-
(2R,3R)-3-hydroxy-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one;
With
trifluoromethane sulfonyl chloride; triethylamine;
In
dichloromethane;
at -40 - -25 ℃;
for 34h;
With
sodium azide;
In
DMF (N,N-dimethyl-formamide);
at -10 - 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trifluoromethane sulfonyl chloride; triethylamine / dichloromethane / 34 h / -40 - -25 °C
1.2: 2 h / -10 - 20 °C
2.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water / 2 h
3.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
6.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.5 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; trifluoromethane sulfonyl chloride; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
5%-palladium/activated carbon;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
