Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester

Base Information

Chemical Name:Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester
CAS No.:680591-65-5
Molecular Formula:C15H28N2O4
Molecular Weight:300.398
Hs Code.:

Synonyms:

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Chemical Property of Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester

There total 11 articles about Glycine, N-[(1R,2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5
(1S,2S)-trans-2-aminocyclohexanol

: 680591-65-5
N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]glycine ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate

2: DMAP; pyridine / 5 h / 0 - 5 °C

3: NaN₃ / dimethylformamide / 18 h / 72 °C

4: H₂ / PtO₂ / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr

5: KF-Celite / acetonitrile / 4 h / 20 °C

With pyridine; dmap; potassium fluoride; sodium azide; hydrogen; platinum(IV) oxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol034933m

Reference yield:

: 119479-49-1
(1S,2S)-trans-2-azidocyclohexanol

: 680591-65-5
N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]glycine ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / PtO₂ / ethyl acetate / 20 °C / 1810.02 - 2068.59 Torr

2: 97.9 percent / pyridine; DMAP / 0 °C

3: NaN₃ / dimethylformamide / 65 - 70 °C

4: H₂ / PtO₂ / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr

5: KF/Celite / acetonitrile / 20 °C

With pyridine; dmap; potassium fluoride; sodium azide; Celite; hydrogen; platinum(IV) oxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo035747x

Reference yield:

: trans-2-azido-1-cyclohexanol

: 680591-65-5
N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]glycine ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine; DMAP / 16 h / 20 °C

2: lipase Amano-PS; aq. phosphate buffer / 2.5 h / pH 7.2

3: MeONa / methanol

4: H₂ / PtO₂ / ethyl acetate / 20 °C / 1810.02 - 2068.59 Torr

5: 97.9 percent / pyridine; DMAP / 0 °C

6: NaN₃ / dimethylformamide / 65 - 70 °C

7: H₂ / PtO₂ / methanol / 3 h / 20 °C / 1810.02 - 2068.59 Torr

8: KF/Celite / acetonitrile / 20 °C

With pyridine; dmap; potassium fluoride; sodium azide; phosphate buffer; Celite; lipase Amano-PS; hydrogen; sodium methylate; platinum(IV) oxide; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo035747x