N-ACETYL-5-BENZYLOXYTRYPTAMINE

Base Information

• Chemical Name: N-ACETYL-5-BENZYLOXYTRYPTAMINE
• CAS No.: 68062-88-4
• Molecular Formula: C19H20N2O2
• Molecular Weight: 308.38
• Mol file: 68062-88-4.mol

Synonyms:5-Benzyloxy-N-acetyltryptamin;N-{2-[5-(benzyloxy)-1H-indol-3-yl]ethyl}acetamide;N-[2-(5-benzyloxy-indol-3-yl)-ethyl]-acetamide;N-Acetyl-5-benzyloxytryptamine;

Chemical Property of N-ACETYL-5-BENZYLOXYTRYPTAMINE

Chemical Property:

• Melting Point: 132-133 °C(Solv: benzene (71-43-2))
• Boiling Point: 592.9±45.0 °C(Predicted)
• PKA: 16.25±0.46(Predicted)
• PSA: 57.25000
• Density: 1.193±0.06 g/cm3(Predicted)
• LogP: 4.08190

Purity/Quality:

98% ^*data from raw suppliers

N-ACETYL-5-BENZYLOXYTRYPTAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ACETYL-5-BENZYLOXYTRYPTAMINE

There total 8 articles about N-ACETYL-5-BENZYLOXYTRYPTAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-benzyloxytryptamine (20776-45-8) + acetic anhydride (108-24-7) → N‐{2‐[5‐(benzyloxy)‐1H‐indol‐3‐yl]ethyl}acetamide (68062-88-4)

Guidance literature:

With hydrogenchloride; sodium acetate; for 1h;

DOI:10.1021/jm950498t

Reference yield:

NSC 73391 (2436-15-9) + acetic anhydride (108-24-7) → N‐{2‐[5‐(benzyloxy)‐1H‐indol‐3‐yl]ethyl}acetamide (68062-88-4)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 20 ℃; for 20h; Inert atmosphere;

DOI:10.1002/ardp.201100125

Reference yield:

5-benzyloxy-1H-indole (1215-59-4) → N‐{2‐[5‐(benzyloxy)‐1H‐indol‐3‐yl]ethyl}acetamide (68062-88-4)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid

2: N,N-dimethyl-formamide; water / 80 °C

3: lithium aluminium tetrahydride / diethyl ether / 0 °C

4: triethylamine / dichloromethane

With lithium aluminium tetrahydride; acetic acid; triethylamine; In diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

5-benzyloxytryptamine

acetic anhydride

NSC 73391

acetylcoenzyme A

Downstream raw materials:

N-acetyl-5-hydroxytryptamine

5-(Nonyloxy)tryptamine

C₂₀H₂₂N₂O₂

C₂₁H₂₄N₂O₂