Benzenesulfonamide, N-[(2S)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-hydroxyhexyl]-4-methyl -N-[(1R)-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2-phenylethyl]-

Base Information

Chemical Name:Benzenesulfonamide, N-[(2S)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-hydroxyhexyl]-4-methyl -N-[(1R)-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2-phenylethyl]-
CAS No.:680974-95-2
Molecular Formula:C35H51NO7S2Si
Molecular Weight:690.01
Hs Code.:

Benzenesulfonamide,
N-[(2S)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-hydroxyhexyl]-4-methyl
-N-[(1R)-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2-phenylethyl]-

Synonyms:

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Chemical Property of Benzenesulfonamide, N-[(2S)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-hydroxyhexyl]-4-methyl -N-[(1R)-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2-phenylethyl]-

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Technology Process of Benzenesulfonamide, N-[(2S)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-hydroxyhexyl]-4-methyl -N-[(1R)-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2-phenylethyl]-

There total 6 articles about Benzenesulfonamide, N-[(2S)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-hydroxyhexyl]-4-methyl -N-[(1R)-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-2-phenylethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 680974-94-1
N-[6-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-hexyl]-N-(1-hydroxymethyl-2-phenyl-ethyl)-4-methyl-benzenesulfonamide

: 680974-95-2
Toluene-4-sulfonic acid (R)-2-[[(S)-6-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-hexyl]-(toluene-4-sulfonyl)-amino]-3-phenyl-propyl ester

: C₄₂H₅₇NO₉S₃Si

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 23 ℃; for 3.2h; Title compound not separated from byproducts;
DOI:10.1021/ol049861t

Reference yield:

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 680974-95-2
Toluene-4-sulfonic acid (R)-2-[[(S)-6-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-hexyl]-(toluene-4-sulfonyl)-amino]-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / propan-1-ol / 17 h / Heating

2: 96 percent / tetrahydrofuran / 0 - 23 °C

3: 93 percent / Et₃N; pyridine / 1.33 h / 23 °C

4: 95 percent / MeONa; MeOH / 0.67 h / 23 °C

5: Et₃N; DMAP / CH₂Cl₂ / 3.2 h / 23 °C

With pyridine; methanol; dmap; sodium methylate; triethylamine; In tetrahydrofuran; propan-1-ol; dichloromethane;
DOI:10.1021/ol049861t

Reference yield:

: 429687-44-5
(S)-2-[4-(tert-butyldimethylsilyloxy)-1-butyl]oxirane

: 680974-95-2
Toluene-4-sulfonic acid (R)-2-[[(S)-6-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-hexyl]-(toluene-4-sulfonyl)-amino]-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / propan-1-ol / 17 h / Heating

2: 96 percent / tetrahydrofuran / 0 - 23 °C

3: 93 percent / Et₃N; pyridine / 1.33 h / 23 °C

4: 95 percent / MeONa; MeOH / 0.67 h / 23 °C

5: Et₃N; DMAP / CH₂Cl₂ / 3.2 h / 23 °C

With pyridine; methanol; dmap; sodium methylate; triethylamine; In tetrahydrofuran; propan-1-ol; dichloromethane;
DOI:10.1021/ol049861t