3,3-Difluorocyclobutylmethyl tosylate

Base Information

• Chemical Name: 3,3-Difluorocyclobutylmethyl tosylate
• CAS No.: 681128-40-5
• Molecular Formula: C12H14F2O3S
• Molecular Weight: 276.304
• Mol file: 681128-40-5.mol

Synonyms:(3,3-difluorocyclobutyl)methyl-4-methylbenzenesulfonate;(3,3-difluorocyclobutyl)methyl 4-methylbenzenesulfonate;toluene-4-sulfonic acid (3,3-difluorocyclobutyl)methyl ester;Toluene-4-sulfonic acid 3,3-difluoro-cyclobutylmethyl ester;

Chemical Property of 3,3-Difluorocyclobutylmethyl tosylate

Chemical Property:

• PSA: 51.75000
• LogP: 3.82640

Purity/Quality:

99% ^*data from raw suppliers

3,3-Difluorocyclobutylmethyltosylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-Difluorocyclobutylmethyl tosylate

There total 3 articles about 3,3-Difluorocyclobutylmethyl tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(3,3-difluorocyclobutyl)methanol (681128-39-2) + p-toluenesulfonyl chloride (98-59-9) → (3,3-difluorocyclobutyl)methyl 4-methylbenzene-1-sulfonate (681128-40-5)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

3,3-difluorocyclobutanecarboxylic acid (107496-54-8) → (3,3-difluorocyclobutyl)methyl 4-methylbenzene-1-sulfonate (681128-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -45 °C

2: pyridine / tetrahydrofuran / 16 h / 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

Reference yield:

→ (3,3-difluorocyclobutyl)methyl 4-methylbenzene-1-sulfonate (681128-40-5)

Guidance literature:

With pyridine; at 20 ℃;

upstream raw materials:

(3,3-difluorocyclobutyl)methanol

p-toluenesulfonyl chloride

3,3-difluorocyclobutanecarboxylic acid

Downstream raw materials:

2-(3,3-difluorocyclobutyl)acetonitrile

({[(3,3-difluorocyclobutyl)methyl]thio}methyl)benzene

2-(3,3-difluorocyclobutyl)acetic acid