Bicyclo[4.2.0]octane-7-carboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S,6R,7R)-

Base Information

Chemical Name:Bicyclo[4.2.0]octane-7-carboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S,6R,7R)-
CAS No.:681146-44-1
Molecular Formula:C31H50O3Si
Molecular Weight:498.822
Hs Code.:

Bicyclo[4.2.0]octane-7-carboxylic acid,
6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester,
(1S,6R,7R)-

Synonyms:

Suppliers and Price of Bicyclo[4.2.0]octane-7-carboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S,6R,7R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bicyclo[4.2.0]octane-7-carboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S,6R,7R)-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bicyclo[4.2.0]octane-7-carboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S,6R,7R)-

There total 1 articles about Bicyclo[4.2.0]octane-7-carboxylic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (1S,6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 62791-22-4
tert-butyl(cyclohex-1-en-1-yloxy)dimethylsilane

: 72526-00-2
(-)-8-phenylmenthyl acrylate

: 681146-44-1
(1R,6S,8R)-1-(tert-butyldimethylsiloxy)-8-[(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyloxycarbonyl]bicyclo[4.2.0]octane

: 681146-47-4
(1S,6R,8R)-1-(tert-butyldimethylsiloxy)-8-[(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyloxycarbonyl]bicyclo[4.2.0]octane

Guidance literature:: With ethylaluminum dichloride; In hexane; dichloromethane; at -78 ℃; for 0.833333h;
DOI:10.1016/j.tet.2003.12.054

Reference yield:

: 681146-44-1
(1R,6S,8R)-1-(tert-butyldimethylsiloxy)-8-[(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyloxycarbonyl]bicyclo[4.2.0]octane

: 681146-84-9
(1R,6S,8R)-1-(tert-butyldimethylsiloxy)-8-(o-nitrophenylselanylmethyl)bicyclo[4.2.0]octane

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / DIBAL-H / CH₂Cl₂; hexane / 1.17 h / -78 °C

2: 88 percent / tributylphosphine / tetrahydrofuran / 22.5 h / 20 - 50 °C

With tributylphosphine; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tet.2003.12.054