5-Hydroxythiabendazole

Base Information

• Chemical Name: 5-Hydroxythiabendazole
• CAS No.: 948-71-0
• Molecular Formula: C10H7 N3 O S
• Molecular Weight: 217.251
• Hs Code.: 2934999090
• European Community (EC) Number: 635-206-5
• DSSTox Substance ID: DTXSID90241627
• Nikkaji Number: J586.238H
• Wikidata: Q83125171
• Mol file: 948-71-0.mol

Synonyms:5-hydroxythiabendazole

Chemical Property of 5-Hydroxythiabendazole

Chemical Property:

• Vapor Pressure: 1.15E-11mmHg at 25°C
• Boiling Point: 525.6°Cat760mmHg
• Flash Point: 271.7°C
• PSA: 90.04000
• Density: 1.535g/cm³
• LogP: 2.39200
• Storage Temp.: 0-6°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 217.03098303
• Heavy Atom Count: 15
• Complexity: 241

Purity/Quality:

98%Min ^*data from raw suppliers

5-HydroxyThiabendazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC2=C(C=C1O)NC(=N2)C3=CSC=N3
• Description: 5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole . Unlike thiabendazole, 5-OH TBZ has no effect on the growth of third-stage A. caninum larvae.
• Uses: Labelled 5-Hydroxy Thiabendazole (H961200) A major metabolite of Thiabendazole 5-Hydroxy Thiabendazole is the major metabolite of Thiabendazole

Technology Process of 5-Hydroxythiabendazole

There total 2 articles about 5-Hydroxythiabendazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(6-methoxy-1H-benzo[d]imidazol-2-yl)thiazole (1614-04-6) → 5-Hydroxy-2-<4-thiazolyl>-benzimidazol (948-71-0)

Guidance literature:

With pyridine hydrochloride; at 220 - 240 ℃;

DOI:10.1021/jm00334a002

Reference yield:

thiabendazole (148-79-8,98002-42-7) → 5-Hydroxythiabendazole (948-71-0)

Guidance literature:

With proadifen; NADPH; rabbit liver microsome; In phosphate buffer; at 37 ℃; pH=7.4; Further Variations:; Reagents; Enzyme kinetics;

DOI:10.3109/00498259609046747

Reference yield:

phthalic anhydride (85-44-9) + 5-Hydroxythiabendazole (948-71-0) → C18H11N3O4S

Guidance literature:

With pyridine; In dimethyl sulfoxide; at 80 ℃; for 10h;

upstream raw materials:

4-(6-methoxy-1H-benzo[d]imidazol-2-yl)thiazole

thiabendazole