6-methoxy-N-(3-sulfopropyl)quinolinium

Base Information

• Chemical Name: 6-methoxy-N-(3-sulfopropyl)quinolinium
• CAS No.: 83907-40-8
• Molecular Formula: C13H15 N O4 S
• Molecular Weight: 281.33
• Hs Code.: 2933499090
• European Community (EC) Number: 695-415-2
• DSSTox Substance ID: DTXSID101347145
• Mol file: 83907-40-8.mol

Synonyms:6-M-SPQ;6-methoxy-N-(3-sulfopropyl)quinolinium

Chemical Property of 6-methoxy-N-(3-sulfopropyl)quinolinium

Chemical Property:

• Melting Point: 299°C dec.
• PSA: 78.69000
• LogP: 2.15200
• Storage Temp.: -20°C Freezer
• Solubility.: Soluble in water, dimethyl sulfoxide
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 281.07217913
• Heavy Atom Count: 19
• Complexity: 365

Purity/Quality:

98%min ^*data from raw suppliers

6-Methoxy-N-(3-sulfopropyl)quinolinium ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)[N+](=CC=C2)CCCS(=O)(=O)[O-]
• Recent ClinicalTrials: Primaquine Enantiomers in G6PD Deficient Human Volunteers
• Description: SPQ is a fluorescent chloride indicator. Its fluorescence is rapidly quenched by chloride in vitro. It has been used to assess voltage-sensitive chloride transport in placental microvillus vesicles. It has also been used to continuously quantify intracellular calcium efflux induced by parathyroid hormone, forskolin , and phorbol 12-myristate 13-acetate (PMA; ) in isolated human erythrocytes. In addition, SPQ has been used to determine the type of ion conductance induced by the cystic fibrosis transmembrane conductance regulator (CFTR) in HEK293 cells expressing pTrial10-CRTR2. SPQ displays excitation maxima of 320 and 350 nm and an emission maximum of 445 nm.
• Uses: SPQ offers a simple and yet powerful method to examine and measure membrane chloride transport mechanisms.

Technology Process of 6-methoxy-N-(3-sulfopropyl)quinolinium

There total 1 articles about 6-methoxy-N-(3-sulfopropyl)quinolinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,3-propanesultone (1120-71-4) + 6-methoxy quinoline (5263-87-6) → 6-(methoxy)-1-(3-sulfonatopropyl)-quinolinium (83907-40-8)

Guidance literature:

for 0.00416667h; microvawe irradiation;

DOI:10.1016/S0040-4039(98)02301-6

upstream raw materials:

1,3-propanesultone

6-methoxy quinoline

Refernces

• 1、 Wolfbeis, Otto S.,Urbano, Edmund. "Syntheses of Fluorescent Dyes. XIV. Standards for Fluorescent Measurements in the Near Neutral pH-Range". . p. 841 - 843. Retrieved 2007/10/02.