Piperidine, 4-[4-[1-(1H-benzimidazol-2-ylmethyl)-4-piperidinyl]-1-piperazinyl]-1-[3,5 -bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-, (2R,4S)-

Base Information

Chemical Name:Piperidine, 4-[4-[1-(1H-benzimidazol-2-ylmethyl)-4-piperidinyl]-1-piperazinyl]-1-[3,5 -bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-, (2R,4S)-
CAS No.:681290-35-7
Molecular Formula:C38H42F6N6O
Molecular Weight:712.781
Hs Code.:

Piperidine,
4-[4-[1-(1H-benzimidazol-2-ylmethyl)-4-piperidinyl]-1-piperazinyl]-1-[3,5
-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-, (2R,4S)-

Synonyms:

Suppliers and Price of Piperidine, 4-[4-[1-(1H-benzimidazol-2-ylmethyl)-4-piperidinyl]-1-piperazinyl]-1-[3,5 -bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-, (2R,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Piperidine, 4-[4-[1-(1H-benzimidazol-2-ylmethyl)-4-piperidinyl]-1-piperazinyl]-1-[3,5 -bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-, (2R,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Piperidine, 4-[4-[1-(1H-benzimidazol-2-ylmethyl)-4-piperidinyl]-1-piperazinyl]-1-[3,5 -bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-, (2R,4S)-

There total 11 articles about Piperidine, 4-[4-[1-(1H-benzimidazol-2-ylmethyl)-4-piperidinyl]-1-piperazinyl]-1-[3,5 -bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-, (2R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 681290-30-2
C₃₀H₃₆F₆N₄O

: 4857-04-9
2-chloromethyl-1H-benzimidazole

: 681290-35-7
C₃₈H₄₂F₆N₆O

Guidance literature:: With potassium carbonate; In acetonitrile; for 12h; Heating / reflux;

Reference yield:

: (+/-)-8-tert-butoxycarbonyl-7-(phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane

: 681290-35-7
C₃₈H₄₂F₆N₆O

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / toluene / 2 h / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 50 °C

3.1: toluene / 20 °C

4.1: ethanol; water / 20 h / 60 °C

5.1: pyrographite / 2 h / 40 °C

5.2: 20 - 50 °C

6.1: hydrogen / palladium 10% on activated carbon

7.1: thiophene; hydrogen / palladium 10% on activated carbon / methanol / 50 °C

8.1: hydrogen / palladium 10% on activated carbon / methanol

9.1: potassium carbonate / acetonitrile / 12 h / Heating / reflux

With thiophene; potassium tert-butylate; hydrogen; potassium carbonate; pyrographite; palladium 10% on activated carbon; In methanol; ethanol; water; toluene; acetonitrile;

Reference yield:

: 193201-63-7
(±)-7-(phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane

: 681290-35-7
C₃₈H₄₂F₆N₆O

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 20 °C

2.1: ethanol; water / 20 h / 60 °C

3.1: pyrographite / 2 h / 40 °C

3.2: 20 - 50 °C

4.1: hydrogen / palladium 10% on activated carbon

5.1: thiophene; hydrogen / palladium 10% on activated carbon / methanol / 50 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol

7.1: potassium carbonate / acetonitrile / 12 h / Heating / reflux

With thiophene; hydrogen; potassium carbonate; pyrographite; palladium 10% on activated carbon; In methanol; ethanol; water; toluene; acetonitrile;