Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[(1,1 -dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl]-, phenylmethyl ester

Base Information

Chemical Name:Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[(1,1 -dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl]-, phenylmethyl ester
CAS No.:681430-76-2
Molecular Formula:C27H31N5O7
Molecular Weight:537.572
Hs Code.:

Glycine,
N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[(1,1
-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl]-, phenylmethyl ester

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Chemical Property of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[(1,1 -dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl]-, phenylmethyl ester

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Technology Process of Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[(1,1 -dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl]-, phenylmethyl ester

There total 2 articles about Glycine, N-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-N-[[4-[[(1,1 -dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 20924-05-4
thymidyl acetic acid

: 681430-75-1
(2-tert-butoxycarbonylamino-benzyl-amino)-acetic acid benzyl ester

: 681430-76-2
{(2-tert-butoxycarbonylamino-benzyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tet.2004.01.026

Reference yield:

: 116026-93-8
4--3-pyridinecarboxaldehyde

: 681430-76-2
{(2-tert-butoxycarbonylamino-benzyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaOAc / ethanol / 0.5 h

1.2: 43 percent / NaBH₃CN / ethanol / 7 h

2.1: 78 percent / EDC / dimethylformamide / 20 °C

With sodium acetate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.01.026