4-[4-(4-Chlorophenoxy)piperidin-1-yl]phenol

Base Information

Chemical Name:4-[4-(4-Chlorophenoxy)piperidin-1-yl]phenol
CAS No.:681509-00-2
Molecular Formula:C17H18ClNO2
Molecular Weight:303.788
Hs Code.:
DSSTox Substance ID:DTXSID00582694
Wikidata:Q82474196

Synonyms:681509-00-2;4-[4-(4-Chlorophenoxy)piperidin-1-yl]phenol;SCHEMBL13279818;DTXSID00582694

Suppliers and Price of 4-[4-(4-Chlorophenoxy)piperidin-1-yl]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-[4-(4-Chlorophenoxy)piperidin-1-yl]phenol

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:303.1026065
Heavy Atom Count:21
Complexity:304

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1OC2=CC=C(C=C2)Cl)C3=CC=C(C=C3)O

Technology Process of 4-[4-(4-Chlorophenoxy)piperidin-1-yl]phenol

There total 3 articles about 4-[4-(4-Chlorophenoxy)piperidin-1-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026355-30-5
4-(4-chloro-phenoxy)-1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-piperidine

: 681509-00-2
4-[4-(4-chlorophenoxy)piperidin-1-yl]phenol

Guidance literature:: With ethanol; pyridinium p-toluenesulfonate; at 70 ℃; for 24h;
DOI:10.1021/jm060957y

Reference yield:

: 36603-49-3
4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

: 681509-00-2
4-[4-(4-chlorophenoxy)piperidin-1-yl]phenol

Guidance literature:: Multi-step reaction with 2 steps

1: Cs₂CO₃ / Pd(OAc)2; rac-BINAP / toluene / 0.5 h / Heating

2: EtOH / pyridinium p-toluenesulfonate / 24 h / 70 °C

With ethanol; caesium carbonate; palladium diacetate; pyridinium p-toluenesulfonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;
DOI:10.1021/jm060957y

Reference yield:

: 97839-99-1
4-(4-chlorophenoxy)-piperidine

: 681509-00-2
4-[4-(4-chlorophenoxy)piperidin-1-yl]phenol

Guidance literature:: Multi-step reaction with 2 steps

1: Cs₂CO₃ / Pd(OAc)2; rac-BINAP / toluene / 0.5 h / Heating

2: EtOH / pyridinium p-toluenesulfonate / 24 h / 70 °C

With ethanol; caesium carbonate; palladium diacetate; pyridinium p-toluenesulfonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;
DOI:10.1021/jm060957y