1-Methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one

Base Information

Chemical Name:1-Methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one
CAS No.:68164-52-3
Molecular Formula:C21H23NO2
Molecular Weight:321.419
Hs Code.:
DSSTox Substance ID:DTXSID90497501

Synonyms:1-Methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one;68164-52-3;DTXSID90497501

Suppliers and Price of 1-Methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-Methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:321.172878976
Heavy Atom Count:24
Complexity:435

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCC(=O)C(C1)C(CC(=O)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-Methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one

There total 3 articles about 1-Methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 94-41-7
benzalacetophenone

: (S)-1-methyl-3-((S)-3-oxo-1,3-diphenylpropyl)piperidin-4-one

: 1198082-67-5
(R)-1-methyl-3-((R)-3-oxo-1,3-diphenylpropyl)piperidin-4-one

: 68164-52-3
C₂₁H₂₃NO₂

Guidance literature:: With (S)-2-((1-(pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methoxy)isoindoline-1,3-dione; benzoic acid; In neat (no solvent); at 20 ℃; for 108h; Overall yield = 83 %; stereoselective reaction;
DOI:10.1016/j.tetasy.2013.11.002

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 94-41-7
benzalacetophenone

: 68164-52-3
1-methyl-3-(3-oxo-1,3-diphenylpropyl)piperidin-4-one

: (S)-1-methyl-3-((S)-3-oxo-1,3-diphenylpropyl)piperidin-4-one

: 1198082-67-5
(R)-1-methyl-3-((R)-3-oxo-1,3-diphenylpropyl)piperidin-4-one

Guidance literature:: With 2-(((S)-pyrrolidin-2-yl)methoxy)pyridine; In tert-butyl alcohol; at 20 ℃; for 48h; optical yield given as %de; enantioselective reaction;
DOI:10.1016/j.tet.2009.09.001