1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

Base Information

Chemical Name:1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol
CAS No.:681803-09-8
Molecular Formula:C18H27ClN2O
Molecular Weight:322.878
Hs Code.:
DSSTox Substance ID:DTXSID00439058
ChEMBL ID:CHEMBL1186412

Synonyms:1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol;681803-09-8;CHEMBL461705;1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol Dihydrochloride;SCHEMBL3955237;CHEMBL1186412;DTXSID00439058;PZQVDLYPNAADGQ-UHFFFAOYSA-N;BDBM50243501;PD091818

Suppliers and Price of 1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:322.1811912
Heavy Atom Count:22
Complexity:340

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)(C(CN2CCNCC2)C3=CC(=CC=C3)Cl)O

Technology Process of 1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

There total 2 articles about 1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 850466-00-1
tert-butyl 4-[2-(3-chlorophenyl)-2-(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate

: 681803-09-8
1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

Guidance literature:: tert-butyl 4-[2-(3-chlorophenyl)-2-(1-hydroxycyclohexyl)acetyl]piperazine-1-carboxylate; With borane; In tetrahydrofuran; at 70 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; at 70 ℃; for 1h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: C₂₃H₃₅ClN₂O₃

: 681803-09-8
1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

Guidance literature:: With hydrogenchloride; In water; at 70 ℃; for 1h;
DOI:10.1021/jm8002262

Reference yield: 64.0%

: 681803-09-8
1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol

: 3453-33-6
6-methoxynaphthalene-2-carbaldehyde

: 1-(1-(3-chlorophenyl)-2-{4-[(6-methoxy-2-naphthyl)methyl]piperazin-1-yl}ethyl)cyclohexanol Dihydrochloride

Guidance literature:: 1-[1-(3-chlorophenyl)-2-piperazin-1-ylethyl]cyclohexanol; 6-methoxynaphthalene-2-carbaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; for 16h;

With hydrogenchloride; In dichloromethane; water; at 25 ℃; for 16h;