2-AMINO-3-NITRO-5-PICOLINE

Base Information

• Chemical Name: 2-AMINO-3-NITRO-5-PICOLINE
• CAS No.: 7598-26-7
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.14
• Hs Code.: 29333999
• Mol file: 7598-26-7.mol

Synonyms:3-Picoline,6-amino-5-nitro- (8CI);(5-Methyl-3-nitropyridin-2-yl)amine;2-Amino-3-nitro-5-methylpyridine;5-Methyl-3-nitro-2-aminopyridine;NSC 403371;

Chemical Property of 2-AMINO-3-NITRO-5-PICOLINE

Chemical Property:

• Appearance/Colour: Ochre crystalline powder
• Vapor Pressure: 0.00035mmHg at 25°C
• Melting Point: 189-193 °C
• Refractive Index: 1.624
• Boiling Point: 318.9 °C at 760 mmHg
• PKA: 2.54±0.49(Predicted)
• Flash Point: 146.7 °C
• PSA: 84.73000
• Density: 1.354 g/cm³
• LogP: 1.98480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%, ^*data from raw suppliers

5-Methyl-3-nitropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-NITRO-5-PICOLINE

There total 5 articles about 2-AMINO-3-NITRO-5-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3-aminomethacrylaldehyde (91752-76-0) + 1,1-diamino-2-nitroethene (71090-35-2) → 5-Methyl-3-nitro-2-aminopyridine (7598-26-7,67476-74-8)

Guidance literature:

With acetic acid; In ethanol; for 15h; Heating;

DOI:10.1002/ardp.19923251208

Reference yield: 28.2%

5-methyl-2-nitraminopyridine (7464-15-5) → 5-Methyl-3-nitro-2-aminopyridine (7598-26-7,67476-74-8)

Guidance literature:

In methanol; for 0.666667h; Quantum yield; Irradiation;

Reference yield: 27.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 5-Methyl-3-nitro-2-aminopyridine (7598-26-7,67476-74-8)

Guidance literature:

(5-methyl-pyridin-2-yl)amine; With sulfuric acid; at -10 - 20 ℃; for 1h;

With nitric acid; In water; at 55 - 60 ℃; for 0.5h;

With sodium hydroxide; In water; at 0 ℃; pH=9;

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

5-methyl-2-nitraminopyridine

3-aminomethacrylaldehyde

1,1-diamino-2-nitroethene

Downstream raw materials:

3-methyl-5-nitro-pyridine-2,6-diyldiamine

2,3-diamino-5-methyl-pyridine

2-bromo-5-methyl-3-nitropyridine

5-methylpyridin-3-amine

Refernces

• 1、 Cai, Sui Xiong,Huang, Jin-Cheng,Espitia, Stephen A.,Tran, Minhtam,Ilyin, Victor I.,Hawkinson, Jon E.,Woodward, Richard M.,Weber, Eckard,Keana, John F.W.. "5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: Novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors". . p. 3679 - 3686. Retrieved 2007/10/03.
• 2、 Troschutz,Luckel. "Nitroketenaminals, VII: Synthesis of substituted 2-amino-3-nitropyridines from 1,3-biselectrophiles and 2-nitroethen-1,1-diamine". . p. 785 - 789. Retrieved 2007/10/02.