POLYCAPROLACTONE AVERAGE MN CA. 42 500

Base Information

• Chemical Name: POLYCAPROLACTONE AVERAGE MN CA. 42 500
• CAS No.: 24980-41-4
• Molecular Formula: C6H10O2
• Molecular Weight: 114.1424
• Hs Code.: 3907998090
• Mol file: 24980-41-4.mol

Synonyms:.epsilon.-Caprolactone,homopolymer;2-Oxepanone,homopolymer;aquaplast,caprolactone;POLYCAPROLACTONE AVERAGE MN CA. 42 500;POLYCAPROLACTONE, AVERAGE MN CA. 10,000;POLYCAPROLACTONE, AVERAGE MN CA. 80,000;POLY(EPSILON-CAPROLACTONE) (AVERAGE MW ABOUT 10,000);caprolactone homopolymer

Chemical Property of POLYCAPROLACTONE AVERAGE MN CA. 42 500

Chemical Property:

• Vapor Pressure: 0.0866mmHg at 25°C
• Melting Point: 60 °C(lit.)
• Boiling Point: 225.4°Cat760mmHg
• Flash Point: 84.8°C
• PSA: 26.30000
• Density: 1.021g/cm³
• LogP: 1.10360
• Storage Temp.: -20°C

Purity/Quality:

98%Min ^*data from raw suppliers

Polycaprolactone viscosity0.20?dL/g ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Polycaprolactone is a semi-crystalline polymer, a chemically synthesized biodegradable polymer material, its structural repeating unit has 5 non-polar methylene-CH2 starch, etc. Substance blending can make completely biodegradable materials.
• Uses: Biodegradable, biocompatible, and bioresorbable polymer composed of ε-caprolactone. This semi-crystalline material has been used in the fabrication of research medical devices and research tissue engineering solutions, such as orthopedic or soft tissue fixation devices. Degradation of this material has been thoroughly studied and has been shown to be safely resorbed by the body after implantation. Modification of molecular weight and polymer composition allows for control of the degradation rate and mechanical stability of the polymer. Extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters. Research applications of this material include:Tissue engineering scaffolds.3D Bioprinting.Drug delivery applications such as sustained release.

Technology Process of POLYCAPROLACTONE AVERAGE MN CA. 42 500

There total 209 articles about POLYCAPROLACTONE AVERAGE MN CA. 42 500 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-dimethylbenzhydrol (885-77-8) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) + bis(p-methylphenyl)-methanone (611-97-2)

Guidance literature:

4,4'-dimethylbenzhydrol; cyclohexanone; With N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile); oxygen; In ethyl acetate; at 75 ℃; for 8h;

With bis(3-trifluoromethyl) diselenide; In 2,2,2-trifluoroethanol; ethyl acetate; at 30 ℃; for 6h;

Reference yield: 85.0%

Adipic acid (124-04-9) → hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2)

Guidance literature:

With hydrogen; In water; at 375 ℃; for 5h;

Reference yield: 43.0%

7,15,16-Trioxa-dispiro[5.1.6.2]hexadecane (185614-71-5) → hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) + oxocan-2-one (539-87-7) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + cycloheptanone (502-42-1)

Guidance literature:

With titanium tetrachloride; at -78 ℃; Further Variations:; Reagents; Temperatures; Product distribution;

DOI:10.1039/b001391i

upstream raw materials:

tetrahydrofuran

Ketene

6-Hydroxyhexanoic acid

N-nitroso-6-caprolactam

Downstream raw materials:

5-hexenoic acid

7-Hydroxy-1-(triphenyl-λ⁵-phosphanylidene)-heptan-2-one

(5-carboxypentyl)triphenylphosphonium bromide

6-hydroxy-2-hexenoic acid ε-lactone

Refernces

• 1、 Li, Xuegeng,Wang, Fan,Lu, Xiaoling,Song, Guoqiang,Zhang, Hao. "A novel method for epoxidation of cyclohexene catalyzed by Fe2O3 with molecular oxygen and aldehydes". . p. 2075 - 2079. Retrieved 1997.
• 2、 Pande, C. S.,Gupta, N.. "Phase Transfer Catalyzed Oxidation of Ketones with Borax - H2O2". . p. 647 - 652. Retrieved 1995.
• 3、 Wedde, Severin,Rommelmann, Philipp,Scherkus, Christian,Schmidt, Sandy,Bornscheuer, Uwe T.,Liese, Andreas,Gr?ger, Harald. "An alternative approach towards poly-ε-caprolactone through a chemoenzymatic synthesis: Combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates". . p. 1286 - 1290. Retrieved 2017.
• 4、 Dithugoe, Choaro D.,van Marwijk, Jacqueline,Smit, Martha S.,Opperman, Diederik J.. "An Alcohol Dehydrogenase from the Short-Chain Dehydrogenase/Reductase Family of Enzymes for the Lactonization of Hexane-1,6-diol". . p. 96 - 102. Retrieved 2019.
• 5、 Karcz, Robert,Olszówka, Joanna E.,Napruszewska, Bogna D.,Kry?ciak-Czerwenka, Joanna,Serwicka, Ewa M.,Klimek, Agnieszka,Bahranowski, Krzysztof. "Combined H2O2/nitrile/bicarbonate system for catalytic Baeyer-Villiger oxidation of cyclohexanone to ε-caprolactone over Mg–Al hydrotalcite catalysts". . . Retrieved 2019.
• 6、 Chrobok, Anna. "Baeyer-Villiger oxidation of ketones in ionic liquids using molecular oxygen in the presence of benzaldehyde". . p. 2940 - 2943. Retrieved 2010.
• 7、 Chrobok, Anna. "An efficient tandem oxidation of cyclohexanol to ε-caprolactone with peroxyacids and TEMPO catalyst in ionic liquids as solvents". . p. 391 - 395. Retrieved 2011.
• 8、 Schmidt, Sandy,Scherkus, Christian,Muschiol, Jan,Menyes, Ulf,Winkler, Till,Hummel, Werner,Gr?ger, Harald,Liese, Andreas,Herz, Hans-Georg,Bornscheuer, Uwe T.. "An enzyme cascade synthesis of ε-caprolactone and its oligomers". . p. 2784 - 2787. Retrieved 2015.
• 9、 Oberleitner, Nikolin,Peters, Christin,Muschiol, Jan,Kadow, Maria,Sass, Stefan,Bayer, Thomas,Schaaf, Patricia,Iqbal, Naseem,Rudroff, Florian,Mihovilovic, Marko D.,Bornscheuer, Uwe T.. "An enzymatic toolbox for cascade reactions: A showcase for an in vivo redox sequence in asymmetric synthesis". . p. 3524 - 3528. Retrieved 2013.
• 10、 Hodge, Philip,Houghton, Mark P.,Lee, Michael S. K.. "A Novel Approach to the Synthesis of Cyclic Oligo- and Poly-esters". . p. 581 - 583. Retrieved 1993.