1H-2,1-Benzoxaphosphorin, 1-ethoxy-4-iodo-3-phenyl-, 1-oxide

Base Information

Chemical Name:1H-2,1-Benzoxaphosphorin, 1-ethoxy-4-iodo-3-phenyl-, 1-oxide
CAS No.:682348-73-8
Molecular Formula:C16H14IO3P
Molecular Weight:412.164
Hs Code.:
ChEMBL ID:CHEMBL1086691
DSSTox Substance ID:DTXSID40461474
Nikkaji Number:J2.041.282H

Synonyms:682348-73-8;1H-2,1-Benzoxaphosphorin, 1-ethoxy-4-iodo-3-phenyl-, 1-oxide;CHEMBL1086691;DTXSID40461474

Suppliers and Price of 1H-2,1-Benzoxaphosphorin, 1-ethoxy-4-iodo-3-phenyl-, 1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1H-2,1-Benzoxaphosphorin, 1-ethoxy-4-iodo-3-phenyl-, 1-oxide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:411.97253
Heavy Atom Count:21
Complexity:456

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP1(=O)C2=CC=CC=C2C(=C(O1)C3=CC=CC=C3)I

Technology Process of 1H-2,1-Benzoxaphosphorin, 1-ethoxy-4-iodo-3-phenyl-, 1-oxide

There total 3 articles about 1H-2,1-Benzoxaphosphorin, 1-ethoxy-4-iodo-3-phenyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 639516-92-0
(2-phenylethynyl-phenyl)-phosphonic acid diethyl ester

: 682348-73-8
1-ethoxy-3-phenyl-4-iodobenzo[c][1,2]oxaphosphinine 1-oxide

Guidance literature:: With iodine; In chloroform; at 20 ℃; for 12h;
DOI:10.1021/ol0499506 DOI:10.1016/j.tet.2005.08.032

Reference yield: 15.0%

: 639516-92-0
(2-phenylethynyl-phenyl)-phosphonic acid diethyl ester

: diethyl [2-(2-oxo-2-phenylethyl)phenyl]phosphonate

: 682348-73-8
1-ethoxy-3-phenyl-4-iodobenzo[c][1,2]oxaphosphinine 1-oxide

Guidance literature:: With iodine; In benzene; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2005.08.032

Reference yield:

: 536-74-3
phenylacetylene

: 682348-73-8
1-ethoxy-3-phenyl-4-iodobenzo[c][1,2]oxaphosphinine 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / PdCl₂(PPh₃)2 / dimethylformamide / 4 h / 90 °C

2: 83 percent / I₂ / CHCl₃ / 12 h / 20 °C

With iodine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol0499506