2,5-Diaminohexanedioic acid

Base Information

• Chemical Name: 2,5-Diaminohexanedioic acid
• CAS No.: 1069-33-6
• Molecular Formula: C6H12 N2 O4
• Molecular Weight: 176.172
• Hs Code.: 2922499990
• Mol file: 1069-33-6.mol

Synonyms:2,5-Diaminoadipicacid; NSC 506572; a,d-Diaminoadipic acid

Chemical Property of 2,5-Diaminohexanedioic acid

Chemical Property:

• Vapor Pressure: 4.22E-08mmHg at 25°C
• Melting Point: 280 °C
• Boiling Point: 416.4°Cat760mmHg
• PKA: 2.10±0.28(Predicted)
• Flash Point: 205.6°C
• PSA: 126.64000
• Density: 1.41g/cm³
• LogP: -0.00900

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-DIAMINO-HEXANEDIOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Diaminohexanedioic acid

There total 12 articles about 2,5-Diaminohexanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

dimethyl 2,5-bis(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)hexanedioate (1109-18-8) → 2,5-diaminohexanedioic acid (1069-33-6)

Guidance literature:

With hydrogen bromide; acetic acid; In water; at 115 ℃; for 336h;

DOI:10.1021/jacs.5b12695

Reference yield: 39.0%

dimethyl 2,5-diaminohexanedioate dihydrochloride (1069-28-9) → 2,5-diaminohexanedioic acid (1069-33-6) + 2,5-diazabicyclo<2.2.2>octane-3,6-dione (1004-98-4)

Guidance literature:

With sodium methylate; In methanol; for 48h; Heating;

Reference yield:

1,4-bis-(2-carboxy-benzoylamino)-butane-1,1,4,4-tetracarboxylic acid → 2,5-diaminohexanedioic acid (1069-33-6) + carbon dioxide (124-38-9,18923-20-1) + benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5)

Guidance literature:

upstream raw materials:

2,5-diazido-adipic acid

2,5-bis-(2-carboxy-benzoylamino)-adipic acid

dimethyl 2,5-diaminohexanedioate dihydrochloride

dimethyl 2,5-bis(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)hexanedioate

Refernces

• 1、 Krasnov, V. P.,Zhdanova, E. A.,Korolyova, M. A.,Bukrina, I. M.,Kodess, M. I.,et al.. "Synthesis of stereoisomers of 2,4-diaminoglutaric and 2,5-diaminoadipic acids". . p. 319 - 323. Retrieved 2007/10/03.
• 2、 Sturm,Henry,Thompson,et al.. "Antifilarial agents. Diazabicyclooctanes and diazabicycloheptanes as bridged analogs of diethylcarbamazine". . p. 481 - 487. Retrieved 2007/10/04.