N-cyclopropyl-4-chloroamphetamine

Base Information

• Chemical Name: N-cyclopropyl-4-chloroamphetamine
• CAS No.: 50326-04-0
• Molecular Formula: C12H16 Cl N . Cl H
• Molecular Weight: 246.18
• Mol file: 50326-04-0.mol

Synonyms:Benzeneethanamine,4-chloro-N-cyclopropyl-a-methyl-, hydrochloride (9CI); N-Cyclopropyl-4-chloroamphetaminehydrochloride

Chemical Property of N-cyclopropyl-4-chloroamphetamine

Chemical Property:

• Vapor Pressure: 0.00109mmHg at 25°C
• Boiling Point: 300.9°C at 760 mmHg
• Flash Point: 135.8°C
• PSA: 12.03000
• Density: 1.1g/cm³
• LogP: 4.21590

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-cyclopropyl-4-chloroamphetamine

There total 1 articles about N-cyclopropyl-4-chloroamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-(4-chlorophenyl)-1-methylethyl]cyclopropanamine (22697-82-1) → N-[2-(4-chlorophenyl)-1-methylethyl]cyclopropanamine hydrochloride (50326-04-0)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield: 39.0%

2-bromothiophene-3-carboxylic acid (24287-95-4) + N-[2-(4-chlorophenyl)-1-methylethyl]cyclopropanamine hydrochloride (50326-04-0) → 2-bromo-N-[2-(4-chlorophenyl)-1-methylethyl]-N-cyclopropylthiophene-3-carboxamide

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol; In dichloromethane; at 20 ℃; for 49h; Heating / reflux;

Reference yield: 37.0%

2-(difluoromethyl)benzoic acid (799814-32-7) + N-[2-(4-chlorophenyl)-1-methylethyl]cyclopropanamine hydrochloride (50326-04-0) → N-[2-(4-chlorophenyl)-1-methylethyl]-N-cyclopropyl-2-(difluoromethyl)benzamide

Guidance literature:

2-(difluoromethyl)benzoic acid; N-[2-(4-chlorophenyl)-1-methylethyl]cyclopropanamine hydrochloride; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol; In dichloromethane; at 20 ℃; for 49h; Heating / reflux;

With hydrogenchloride; In dichloromethane; water; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

N-[2-(4-chlorophenyl)-1-methylethyl]cyclopropanamine