Chemical Property of (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide
Chemical Property:
- Melting Point:>300 °C
- PSA：127.21000
- LogP:4.57730
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble0.2mg/mL
- XLogP3:2.4
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:8
- Exact Mass:504.22737416
- Heavy Atom Count:38
- Complexity:856
- Purity/Quality:
-
99% *data from raw suppliers
GW4869 ≥90% (NMR) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CN=C(N1)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)C=CC(=O)NC4=CC=C(C=C4)C5=NCCN5
- Isomeric SMILES:C1NC(=NC1)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(C=C3)/C=C/C(=O)NC4=CC=C(C=C4)C5=NCCN5
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Uses
GW4869 has been used:as an inhibitor of neutral sphingomyelinase and exosome biogenesisto analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide productionto determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats
