2-Pyrrolidinone, 5-[(1R,2S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,3-dihydroxypropyl]- 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(phenylmethyl)-, (5S)-

Base Information

Chemical Name:2-Pyrrolidinone, 5-[(1R,2S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,3-dihydroxypropyl]- 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(phenylmethyl)-, (5S)-
CAS No.:682811-91-2
Molecular Formula:C27H49NO5Si2
Molecular Weight:523.861
Hs Code.:

2-Pyrrolidinone,
5-[(1R,2S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,3-dihydroxypropyl]-
5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(phenylmethyl)-, (5S)-

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Chemical Property of 2-Pyrrolidinone, 5-[(1R,2S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,3-dihydroxypropyl]- 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(phenylmethyl)-, (5S)-

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Technology Process of 2-Pyrrolidinone, 5-[(1R,2S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,3-dihydroxypropyl]- 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(phenylmethyl)-, (5S)-

There total 6 articles about 2-Pyrrolidinone, 5-[(1R,2S)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,3-dihydroxypropyl]- 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-(phenylmethyl)-, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 682811-82-1
(5S)-1-benzyl-5-[(1R)-1-(tert-butyldimethylsilanyloxy)-1-[(4S)-2,2-dimethyl[1,3]dioxolan-4-yl]methyl]-5-[(tert-butyldimethylsilanyloxy)methyl]pyrrolidin-2-one

: 682811-91-2
1-benzyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-2,3-dihydroxy-propyl]-5-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-2-one

Guidance literature:: With cerium(III) chloride; oxalic acid; In acetonitrile; at 40 ℃; for 5h;
DOI:10.1021/jo035846a

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 682811-91-2
1-benzyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-2,3-dihydroxy-propyl]-5-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

2: 92 percent / ceric ammonium nitrate / acetonitrile / 4 h / Heating

3: 84 percent / KH / tetrahydrofuran / 4 h / 50 °C

4: CeCl₃*7H₂O; oxalic acid / acetonitrile / 5 h / 40 °C

With 2,6-dimethylpyridine; cerium(III) chloride; ammonium cerium(IV) nitrate; oxalic acid; potassium hydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo035846a

Reference yield:

: 2-[(tert-butyldimethylsilanyloxy)methyl]-2-[(1R)-1-[(4S)-2,2-dimethyl[1,3]dioxolan-4-yl]-1-hydroxymethyl]-5-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 682811-91-2
1-benzyl-5-[1-(tert-butyl-dimethyl-silanyloxy)-2,3-dihydroxy-propyl]-5-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / NiCl₂*6H₂O; NaBH₄ / methanol / 0 °C

2: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

3: 92 percent / ceric ammonium nitrate / acetonitrile / 4 h / Heating

4: 84 percent / KH / tetrahydrofuran / 4 h / 50 °C

5: CeCl₃*7H₂O; oxalic acid / acetonitrile / 5 h / 40 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; cerium(III) chloride; ammonium cerium(IV) nitrate; oxalic acid; potassium hydride; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo035846a