AMidepsine D

Base Information

• Chemical Name: AMidepsine D
• CAS No.: 79786-34-8
• Molecular Formula: C26H24O10
• Molecular Weight: 496.46
• Mol file: 79786-34-8.mol

Synonyms:AMIDEPSINE D;Amidepsine D, Humcola sp;

Chemical Property of AMidepsine D

Chemical Property:

• PSA: 148.82000
• LogP: 4.17680
• Solubility.: Soluble in DMSO

Purity/Quality:

98%Min ^*data from raw suppliers

Amidepsine D ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp, which inhibits DGAT activity, thus triacylglycerol formation is attenuated and protects against the development of diet-induced obesity or insulin-resistance.

Technology Process of AMidepsine D

There total 3 articles about AMidepsine D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl 2,4-di-O-methylgyrophorate (79786-38-2) → 2,4-di-O-methylgyrophoric acid (79786-34-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 6h;

Reference yield:

2,4-dimethoxy-6-methylbenzoic acid (3686-57-5) → 2,4-di-O-methylgyrophoric acid (79786-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / trifluoroacetic anhydride / toluene / 12 h / Ambient temperature

2: 70 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h

With hydrogen; trifluoroacetic anhydride; palladium on activated charcoal; In ethyl acetate; toluene;

Reference yield:

benzyl lecanorate (61158-13-2) → 2,4-di-O-methylgyrophoric acid (79786-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / trifluoroacetic anhydride / toluene / 12 h / Ambient temperature

2: 70 percent / H₂ / 10percent Pd/C / ethyl acetate / 6 h

With hydrogen; trifluoroacetic anhydride; palladium on activated charcoal; In ethyl acetate; toluene;

upstream raw materials:

benzyl 2,4-di-O-methylgyrophorate

2,4-dimethoxy-6-methylbenzoic acid

benzyl lecanorate

Downstream raw materials:

2-O-methyltenuiorin