1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide

Base Information

• Chemical Name: 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide
• CAS No.: 68352-27-2
• Molecular Formula: C17H12N2O4
• Molecular Weight: 308.293
• European Community (EC) Number: 653-020-2
• ChEMBL ID: CHEMBL2441152

Synonyms:1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide;1-HYDROXY-4'-NITRO-2-NAPHTHANILIDE;CHEMBL2441152;SCHEMBL14428339;AKOS024333352;68352-27-2;1-Hydroxy-N-(4-nitrophenyl)-2-naphthamide

Chemical Property of 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 308.07970687
• Heavy Atom Count: 23
• Complexity: 442

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2O)C(=O)NC3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide

There total 2 articles about 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-nitro-aniline (100-01-6,104810-17-5) + 1-hydroxy-2-naphthoic acid (86-48-6) → 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (68352-27-2)

Guidance literature:

With phosphorus trichloride; In chlorobenzene; at 130 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.bmc.2013.08.030

Reference yield:

→ 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (68352-27-2)

Guidance literature:

1-Hydroxy-naphth-2-oyl-chlorid, 4-Nitro-anilin;

Reference yield:

thiophosgene (463-71-8) + 1-hydroxy-N-(4-nitrophenyl)naphthalene-2-carboxamide (68352-27-2) → 3-(4-nitro-phenyl)-2-thioxo-2,3-dihydro-naphtho[2,1-e][1,3]oxazin-4-one (68352-51-2)

Guidance literature:

With triethylamine;

DOI:10.1021/jm00209a020

upstream raw materials:

4-nitro-aniline

1-hydroxy-2-naphthoic acid

Downstream raw materials:

1-hydroxy-[2]naphthoic acid-(4-amino-anilide)

3-(4-nitro-phenyl)-2-thioxo-2,3-dihydro-naphtho[2,1-e][1,3]oxazin-4-one

3-(4-nitro-phenyl)-naphtho[2,1-e][1,3]oxazine-2,4-dione

1-acetylamino-4-(1-hydroxy-[2]naphthoylamino)-benzene

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