O(2)-Butylthymidine

Base Information

• Chemical Name: O(2)-Butylthymidine
• CAS No.: 82543-40-6
• Molecular Formula: C₁₄H₂₂N₂O₅
• Molecular Weight: 298.339
• Mol file: 82543-40-6.mol

Synonyms:

Chemical Property of O(2)-Butylthymidine

Chemical Property:

• Vapor Pressure: 7.4E-11mmHg at 25°C
• Boiling Point: 471.2°Cat760mmHg
• Flash Point: 238.8°C
• Density: 1.35g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O(2)-Butylthymidine

There total 1 articles about O(2)-Butylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(p-toluenesulfonyl)thymidine (7253-19-2) + butan-1-ol (71-36-3) → O2-nBudT (82543-40-6)

Guidance literature:

With sodium hydrogencarbonate; for 16h; Reflux;

DOI:10.1093/nar/gku748

Reference yield:

O2-nBudT (82543-40-6) → C44H57N4O8P

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; pyridine / 10 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice

With pyridine; dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1093/nar/gku748

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + O2-nBudT (82543-40-6) → C35H40N2O7

Guidance literature:

With pyridine; dmap; at 20 ℃; for 10h; Cooling with ice;

DOI:10.1093/nar/gku748

upstream raw materials:

5'-O-(p-toluenesulfonyl)thymidine

butan-1-ol