Isotubulosine

Base Information

• Chemical Name: Isotubulosine
• CAS No.: 5610-39-9
• Molecular Formula: C29H37N3O3
• Molecular Weight: 475.631
• Mol file: 5610-39-9.mol

Synonyms:(S)-1-((2S,3R,11bS)-3-Ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylmethyl)-2,3,4,9-tetrahydro-1H-β-carbolin-6-ol;

Chemical Property of Isotubulosine

Chemical Property:

• Melting Point: 177-8°C
• Boiling Point: 667.8°Cat760mmHg
• Flash Point: 357.7°C
• PSA: 69.75000
• Density: 1.27g/cm³
• LogP: 5.37980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: A complex alkaloid occurring in Alangium lamarckii Thw., the base yields colourless crystals from EtOH and is laevorotatory with [α]25D - 84° (c 1.0, pyridine). The ultraviolet spectrum has been fully determined. In MeOH it shows a single broad absorption maximum at 279 mJl. In 0.1 N/HC1 there is a very small hypsochromic shift to 277 mJl while in 0.1 N/NaOH, there are two absorp_x0002_tion maxima at 279 and 319 mμ. Two methoxyl groups, two imino groups and one hydroxyl group are present. The latter furnishes the O-methy1 ether, m.p. 163°C;[α]20D - 18.8° (MeOH). The above structure has been confirmed by synthesis.

Technology Process of Isotubulosine

There total 3 articles about Isotubulosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1',2'-dehydrotubulosine → isotubulosine (5610-39-9) + Tubulosine (2632-29-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1021/np0000163

Reference yield:

→ 10,11-dimethoxy-tubolosan-8'-ol (2632-29-3,5610-39-9,16049-31-3,30833-24-0,30833-26-2)

Guidance literature:

O-Benzyl-isotubulosin, H2, Pd/Al2O3, Me., Eg.;

DOI:10.1039/j39690000089

Reference yield:

→ rac.Tubulosin (2632-29-3,5610-39-9,16049-31-3,30833-24-0,30833-26-2)

Guidance literature:

rac.Protoemetin, 5-Hydroxytryptamin-hydrogensulfat/Wasser/AcOH;