Technology Process of 1,3-Propanediol, 2-[2-nitro-4-(phenylmethoxy)-1-naphthalenyl]-,
monoacetate (ester), (2S)-
There total 8 articles about 1,3-Propanediol, 2-[2-nitro-4-(phenylmethoxy)-1-naphthalenyl]-,
monoacetate (ester), (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Pseudomonas sp. lipase; 4 A molecular sieve;
at 35 ℃;
for 20h;
DOI:10.1021/jo035465x
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 92 percent / Bu4NI; K2CO3 / dimethylformamide / 1.25 h / 25 °C
2.1: 78 percent / NaOH / methanol / 3 h / 70 °C
3.1: 76 percent / BF3*OEt2; t-BuONO / 1,2-dimethoxy-ethane / 2 h / -15 - 0 °C
4.1: 75 percent / CuCl; CuCl2 / H2O; acetonitrile / 0 - 25 °C
5.1: NaH / dimethylformamide / 0.5 h / 0 °C
5.2: 86 percent / dimethylformamide / 12 h / 80 °C
6.1: 76 percent / BH3*SMe2 / dioxane / 16 h / 70 °C
7.1: 88 percent / 4 Angstroem molecular sieves; Pseudomonas sp. lipase / 20 h / 35 °C
With
sodium hydroxide; tert.-butylnitrite; Pseudomonas sp. lipase; dimethylsulfide borane complex; 4 A molecular sieve; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; copper(l) chloride; copper dichloride;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo035465x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaH / dimethylformamide / 0.5 h / 0 °C
1.2: 86 percent / dimethylformamide / 12 h / 80 °C
2.1: 76 percent / BH3*SMe2 / dioxane / 16 h / 70 °C
3.1: 88 percent / 4 Angstroem molecular sieves; Pseudomonas sp. lipase / 20 h / 35 °C
With
Pseudomonas sp. lipase; dimethylsulfide borane complex; 4 A molecular sieve; sodium hydride;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jo035465x
