Sulfacarzole

Base Information

• Chemical Name: Sulfacarzole
• CAS No.: 5664-51-7
• Molecular Formula: C12H13ClN4O2S
• Molecular Weight: 299.331
• NSC Number: 41840,35248
• DSSTox Substance ID: DTXSID30972084
• Wikidata: Q82955797
• Mol file: 5664-51-7.mol

Synonyms:Sulfacarzole;5664-51-7;2-(4-Amino-benzenesulfonylamino)-thiazole-5-carboxylic acid;2-[(4-aminophenyl)sulfonylamino]-1,3-thiazole-5-carboxylic acid;5-Thiazolecarboxylic acid, 2-sulfanilamido-;5-Thiazolecarboxylic acid, 2-[[(4-aminophenyl)sulfonyl]amino]-;NSC41840;DTXSID30972084;NSC35248;NSC-35248;NSC-41840;A900540;2-((4-Aminophenyl)sulfonamido)thiazole-5-carboxylic acid;2-(4-aminobenzenesulfonylamino)thiazole-5-carboxylic acid;2-[(4-Aminobenzene-1-sulfonyl)amino]-1,3-thiazole-5-carboxylic acid

Chemical Property of Sulfacarzole

Chemical Property:

• Vapor Pressure: 1.45E-07mmHg at 25°C
• Boiling Point: 606.9°Cat760mmHg
• Flash Point: 320.9°C
• PSA: 159.00000
• Density: 1.7g/cm³
• LogP: 2.95930
• XLogP3: 1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 299.00344812
• Heavy Atom Count: 19
• Complexity: 429

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=C(S2)C(=O)O

Technology Process of Sulfacarzole

There total 3 articles about Sulfacarzole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-chloro-benzenesulfonylamino)-thiazole-5-carboxylic acid ethyl ester (859486-36-5) → 2-sulfanilylamino-thiazole-5-carboxylic acid (5664-51-7)

Guidance literature:

With sodium hydroxide;

Reference yield:

2-[(N-acetyl-sulfanilyl)-amino]-thiazole-5-carboxylic acid → 2-sulfanilylamino-thiazole-5-carboxylic acid (5664-51-7)

Guidance literature:

With sodium hydroxide;

Reference yield:

p-acetylaminobenzenesulfonyl chloride (121-60-8) → 2-sulfanilylamino-thiazole-5-carboxylic acid (5664-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃; acetone

2: aqueous NaOH

With sodium hydroxide; sodium hydrogencarbonate; acetone;

upstream raw materials:

2-(4-chloro-benzenesulfonylamino)-thiazole-5-carboxylic acid ethyl ester

p-acetylaminobenzenesulfonyl chloride

Downstream raw materials:

Sulfathiazole