Technology Process of pantherinine
There total 9 articles about pantherinine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: 86 percent / Na2CO3 / tetrakis(triphenylphosphine)palladium / benzene / 48 h / Heating
2: 97 percent / bromine / CH2Cl2 / 0.17 h / 15 °C
3: 87 percent / 20 percent H2SO4 / H2O / 1 h / Heating
4: Na2S2O4 / tetrahydrofuran; H2O / 0.5 h / 25 °C
5: K2CO3 / tetrahydrofuran / 0.25 h / 15 °C
6: 45 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.25 h / 0 °C
7: 33 percent / 10 percent HCl / methanol / 120 h / 25 °C
With
hydrogenchloride; sodium dithionite; ammonium cerium(IV) nitrate; sulfuric acid; bromine; sodium carbonate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4039(98)01088-0
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 84 percent / POBr3 / Heating
2: 86 percent / Na2CO3 / tetrakis(triphenylphosphine)palladium / benzene / 48 h / Heating
3: 97 percent / bromine / CH2Cl2 / 0.17 h / 15 °C
4: 87 percent / 20 percent H2SO4 / H2O / 1 h / Heating
5: Na2S2O4 / tetrahydrofuran; H2O / 0.5 h / 25 °C
6: K2CO3 / tetrahydrofuran / 0.25 h / 15 °C
7: 45 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.25 h / 0 °C
8: 33 percent / 10 percent HCl / methanol / 120 h / 25 °C
With
hydrogenchloride; sodium dithionite; ammonium cerium(IV) nitrate; sulfuric acid; bromine; sodium carbonate; potassium carbonate; phosphorus(V) oxybromide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4039(98)01088-0