1H-Isoindole, 2,3-dihydro-5-(2-oxo-1-pyrrolidinyl)-2-[4-[3-(1-piperidinyl)propoxy]benzo yl]-

Base Information

Chemical Name:1H-Isoindole, 2,3-dihydro-5-(2-oxo-1-pyrrolidinyl)-2-[4-[3-(1-piperidinyl)propoxy]benzo yl]-
CAS No.:685565-49-5
Molecular Formula:C27H33N3O3
Molecular Weight:447.577
Hs Code.:

Synonyms:

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Chemical Property of 1H-Isoindole, 2,3-dihydro-5-(2-oxo-1-pyrrolidinyl)-2-[4-[3-(1-piperidinyl)propoxy]benzo yl]-

Chemical Property:

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Technology Process of 1H-Isoindole, 2,3-dihydro-5-(2-oxo-1-pyrrolidinyl)-2-[4-[3-(1-piperidinyl)propoxy]benzo yl]-

There total 6 articles about 1H-Isoindole, 2,3-dihydro-5-(2-oxo-1-pyrrolidinyl)-2-[4-[3-(1-piperidinyl)propoxy]benzo yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 685565-47-3
N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-aminoisoindoline

: 4509-90-4
5-bromovaleroyl chloride

: 685565-49-5
N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-(2-oxo-pyrrolidin-1-yl)isoindoline

Guidance literature:: N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-aminoisoindoline; 5-bromovaleroyl chloride; With polystyrene-CH₂NEt₂; In dichloromethane; at 20 ℃; for 0.5h;

With sodium hydride; In DMF (N,N-dimethyl-formamide); for 3h;

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 685565-49-5
N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-(2-oxo-pyrrolidin-1-yl)isoindoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / Heating / reflux

2.1: sodium carbonate; potassium iodide / butan-1-ol / 16 h / 105 °C

3.1: hydrogenchloride / water / 1 - 2 h / Heating / reflux

4.1: thionyl chloride / 1 h / Heating / reflux; Neat (no solvent)

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6.1: hydrogenchloride; titanium(III) chloride / tetrahydrofuran; water / 3 h

7.1: polystyrene-CH₂NEt₂ / dichloromethane / 0.5 h / 20 °C

7.2: 3 h

With hydrogenchloride; thionyl chloride; titanium(III) chloride; polystyrene-CH₂NEt₂; sodium carbonate; potassium carbonate; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; water; acetone; butan-1-ol;

Reference yield:

: N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-nitroisoindoline

: 685565-49-5
N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-(2-oxo-pyrrolidin-1-yl)isoindoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; titanium(III) chloride / tetrahydrofuran; water / 3 h

2.1: polystyrene-CH₂NEt₂ / dichloromethane / 0.5 h / 20 °C

2.2: 3 h

With hydrogenchloride; titanium(III) chloride; polystyrene-CH₂NEt₂; In tetrahydrofuran; dichloromethane; water;