Technology Process of Carbamic acid,
[(1S)-2-hydroxy-1-[(5-hydroxy-4-methoxy-3-methylphenyl)methyl]ethyl]-,
2-propenyl ester
There total 10 articles about Carbamic acid,
[(1S)-2-hydroxy-1-[(5-hydroxy-4-methoxy-3-methylphenyl)methyl]ethyl]-,
2-propenyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Allyl chloroformate; (S)-5-(2-amino-3-hydroxypropyl)-2-methoxy-3-methylphenol;
With
sodium hydrogencarbonate;
In
dichloromethane;
at 20 ℃;
With
potassium carbonate;
In
methanol; dichloromethane;
at 20 ℃;
DOI:10.1055/s-2004-817763
- Guidance literature:
-
Multi-step reaction with 10 steps
1: triethylamine / CH2Cl2 / 4 h / -70 °C
2: 23.5 g / K2CO3 / acetone / 5 h / 50 °C
3: 85 percent / TiCl4 / CH2Cl2 / 20 °C
4: 99 percent / NaBH4 / tetrahydrofuran; methanol; H2O / 1 h / 0 °C
5: 95 percent / PBr3 / CH2Cl2; toluene / 20 °C
6: O-(9)-allyl-N-(9'-anthracenylmethyl)cinchonidium bromide; CsOH*H2O / CH2Cl2 / 30 h / -78 °C
7: AcOH / tetrahydrofuran; H2O / 2 h / 20 °C
8: LiBH4 / diethyl ether; methanol / 20 °C
9: NaOH / ethanol; H2O / 8 h / 80 °C
10: NaHCO3 / H2O; CH2Cl2 / 1 h / 20 °C
With
cesium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium borohydride; phosphorus tribromide; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1021/jo050408k
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 23.5 g / K2CO3 / acetone / 5 h / 50 °C
2: 85 percent / TiCl4 / CH2Cl2 / 20 °C
3: 99 percent / NaBH4 / tetrahydrofuran; methanol; H2O / 1 h / 0 °C
4: 95 percent / PBr3 / CH2Cl2; toluene / 20 °C
5: O-(9)-allyl-N-(9'-anthracenylmethyl)cinchonidium bromide; CsOH*H2O / CH2Cl2 / 30 h / -78 °C
6: AcOH / tetrahydrofuran; H2O / 2 h / 20 °C
7: LiBH4 / diethyl ether; methanol / 20 °C
8: NaOH / ethanol; H2O / 8 h / 80 °C
9: NaHCO3 / H2O; CH2Cl2 / 1 h / 20 °C
With
cesium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium borohydride; phosphorus tribromide; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; acetic acid; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; toluene;
DOI:10.1021/jo050408k
