Dibenzyl hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: Dibenzyl hydrazine-1,2-dicarboxylate
• CAS No.: 5394-50-3
• Molecular Formula: C16H16 N2 O4
• Molecular Weight: 300.314
• Hs Code.: 2928000090
• European Community (EC) Number: 611-069-7
• NSC Number: 3457
• DSSTox Substance ID: DTXSID50277669
• Nikkaji Number: J1.839.894J
• Wikidata: Q82008982
• ChEMBL ID: CHEMBL1875799
• Mol file: 5394-50-3.mol

Synonyms:dibenzyl hydrazine-1,2-dicarboxylate;5394-50-3;benzyl N-(phenylmethoxycarbonylamino)carbamate;Dibenzyl hydrazodicarboxylate;1,2-DICARBOBENZYLOXYHYDRAZINE;MLS002637694;dibenzyl 1,2-hydrazinedicarboxylate;N'-[(benzyloxy)carbonyl](benzyloxy)carbohydrazide;1,2-Dicarbobenzyl-Oxyhydrazine;NSC3457;bis(benzyloxycarbonyl)hydrazine;SCHEMBL2295789;1,2-Hydrazinedicarboxylic acid, bis(phenylmethyl) ester;CHEMBL1875799;DTXSID50277669;HMS3085E15;CS-M0772;dibenzylhydrazine-1,2-dicarboxylate;NSC 3457;NSC-3457;AB6952;MFCD00022028;AKOS015889506;AM805027;AS-44809;SMR001547217;bis(phenylmethyl) 1,2-hydrazinedicarboxylate;FT-0652873;Hydrazine-1,2-dicarboxylic acid dibenzyl ester;A829850

Chemical Property of Dibenzyl hydrazine-1,2-dicarboxylate

Chemical Property:

• Vapor Pressure: 9.9E-09mmHg at 25°C
• Melting Point: 104-105.5 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 462.4°Cat760mmHg
• PKA: 8.52±0.43(Predicted)
• Flash Point: 233.5°C
• PSA: 76.66000
• Density: 1.248g/cm³
• LogP: 3.53600
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 300.11100700
• Heavy Atom Count: 22
• Complexity: 316

Purity/Quality:

99%, ^*data from raw suppliers

1,2-DICARBOBENZYLOXYHYDRAZINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NNC(=O)OCC2=CC=CC=C2

Technology Process of Dibenzyl hydrazine-1,2-dicarboxylate

There total 4 articles about Dibenzyl hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl chloroformate (501-53-1,94274-21-2) → bis(phenylmethyl) 1,2-hydrazinedicarboxylate (5394-50-3)

Guidance literature:

With pyridine; hydrazine hydrate; In tetrahydrofuran; at 0 ℃;

DOI:10.1246/cl.170970

Reference yield: 95.0%

dibenzyl azodicarboxylate (2449-05-0) + 1-benzyl-4-((((3R,5S)-5-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)pyrrolidin-3-yl)oxy)methyl)-1H-1,2,3-triazole → 1-benzyl-4-((((2S,4R)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)-3,4-dihydro-2H-pyrrol-4-yl)oxy)methyl)-1H-1,2,3-triazole + bis(phenylmethyl) 1,2-hydrazinedicarboxylate (5394-50-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1002/adsc.201200887 DOI:10.1002/adsc.201200887

Reference yield:

water (7732-18-5) + hydrazine hydrate (7803-57-8,79785-97-0) + benzyl chloroformate (501-53-1,94274-21-2) → bis(phenylmethyl) 1,2-hydrazinedicarboxylate (5394-50-3)

Guidance literature:

upstream raw materials:

benzyl chloroformate

water

hydrazine hydrate

dibenzyl azodicarboxylate

Downstream raw materials:

tert-butyl 6-O-(tert-butyldimethylsilyl)-3-(N,N'-dicarbobenzyloxyhydrazino)-3,4-dideoxy-4-C-<(trimethylacetoxy)methyl>-α-D-arabino-hexopyranosid-2-ulose

C₃₃H₄₈N₂O₈Si

dibenzyl 5,6,7,8-tetrahydro-2,11,4,9-propane-1,3-diylidene-1,6,7,12-benzotetra-azacyclotetradecine-6,7-dicarboxylate

indazole-1-carboxylic acid benzyl ester