Acetic acid, (diethoxyphosphinyl)-, (1S,3S,4E,6E,8R)-1-[(1S,2R,3E)-2-methoxy-5-[(4-methoxyphenyl)meth oxy]-1,3-dimethyl-3-pentenyl]-4-methyl-8-[(2R,4S)-tetrahydro-6-oxo-4-(2 -oxoethyl)-2H-pyran-2-yl]-3-[[tris(1-methylethyl)silyl]oxy]-4,6-nonadienyl ester

Base Information

Chemical Name:Acetic acid, (diethoxyphosphinyl)-, (1S,3S,4E,6E,8R)-1-[(1S,2R,3E)-2-methoxy-5-[(4-methoxyphenyl)meth oxy]-1,3-dimethyl-3-pentenyl]-4-methyl-8-[(2R,4S)-tetrahydro-6-oxo-4-(2 -oxoethyl)-2H-pyran-2-yl]-3-[[tris(1-methylethyl)silyl]oxy]-4,6-nonadienyl ester
CAS No.:691869-42-8
Molecular Formula:C48H79O12PSi
Molecular Weight:907.207
Hs Code.:

Acetic acid, (diethoxyphosphinyl)-,
(1S,3S,4E,6E,8R)-1-[(1S,2R,3E)-2-methoxy-5-[(4-methoxyphenyl)meth
oxy]-1,3-dimethyl-3-pentenyl]-4-methyl-8-[(2R,4S)-tetrahydro-6-oxo-4-(2
-oxoethyl)-2H-pyran-2-yl]-3-[[tris(1-methylethyl)silyl]oxy]-4,6-nonadienyl
ester

Synonyms:

Suppliers and Price of Acetic acid, (diethoxyphosphinyl)-, (1S,3S,4E,6E,8R)-1-[(1S,2R,3E)-2-methoxy-5-[(4-methoxyphenyl)meth oxy]-1,3-dimethyl-3-pentenyl]-4-methyl-8-[(2R,4S)-tetrahydro-6-oxo-4-(2 -oxoethyl)-2H-pyran-2-yl]-3-[[tris(1-methylethyl)silyl]oxy]-4,6-nonadienyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid, (diethoxyphosphinyl)-, (1S,3S,4E,6E,8R)-1-[(1S,2R,3E)-2-methoxy-5-[(4-methoxyphenyl)meth oxy]-1,3-dimethyl-3-pentenyl]-4-methyl-8-[(2R,4S)-tetrahydro-6-oxo-4-(2 -oxoethyl)-2H-pyran-2-yl]-3-[[tris(1-methylethyl)silyl]oxy]-4,6-nonadienyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid, (diethoxyphosphinyl)-, (1S,3S,4E,6E,8R)-1-[(1S,2R,3E)-2-methoxy-5-[(4-methoxyphenyl)meth oxy]-1,3-dimethyl-3-pentenyl]-4-methyl-8-[(2R,4S)-tetrahydro-6-oxo-4-(2 -oxoethyl)-2H-pyran-2-yl]-3-[[tris(1-methylethyl)silyl]oxy]-4,6-nonadienyl ester

There total 40 articles about Acetic acid, (diethoxyphosphinyl)-, (1S,3S,4E,6E,8R)-1-[(1S,2R,3E)-2-methoxy-5-[(4-methoxyphenyl)meth oxy]-1,3-dimethyl-3-pentenyl]-4-methyl-8-[(2R,4S)-tetrahydro-6-oxo-4-(2 -oxoethyl)-2H-pyran-2-yl]-3-[[tris(1-methylethyl)silyl]oxy]-4,6-nonadienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 850697-82-4
(Diethoxy-phosphoryl)-acetic acid (4E,6E)-(1S,3S,8R)-8-[(2R,4R)-4-(2-hydroxy-ethyl)-6-oxo-tetrahydro-pyran-2-yl]-1-[(E)-(1S,2R)-2-methoxy-5-(4-methoxy-benzyloxy)-1,3-dimethyl-pent-3-enyl]-4-methyl-3-triisopropylsilanyloxy-nona-4,6-dienyl ester

: 691869-42-8
(Diethoxy-phosphoryl)-acetic acid (4E,6E)-(1S,3S,8R)-1-[(E)-(1S,2R)-2-methoxy-5-(4-methoxy-benzyloxy)-1,3-dimethyl-pent-3-enyl]-4-methyl-8-[(2R,4S)-6-oxo-4-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-3-triisopropylsilanyloxy-nona-4,6-dienyl ester

Guidance literature:: With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; at 20 ℃; for 1h;
DOI:10.1055/s-2005-862373

Reference yield: 75.0%

: 691869-41-7
(Diethoxy-phosphoryl)-acetic acid (4E,6E)-(1S,3S,8R,9R)-10-((1S,3R,4S)-3,4-dihydroxy-cyclopentyl)-9-hydroxy-1-[(E)-(1S,2R)-2-methoxy-5-(4-methoxy-benzyloxy)-1,3-dimethyl-pent-3-enyl]-4,8-dimethyl-3-triisopropylsilanyloxy-deca-4,6-dienyl ester

: 691869-42-8
(Diethoxy-phosphoryl)-acetic acid (4E,6E)-(1S,3S,8R)-1-[(E)-(1S,2R)-2-methoxy-5-(4-methoxy-benzyloxy)-1,3-dimethyl-pent-3-enyl]-4-methyl-8-[(2R,4S)-6-oxo-4-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-3-triisopropylsilanyloxy-nona-4,6-dienyl ester

Guidance literature:: (Diethoxy-phosphoryl)-acetic acid (4E,6E)-(1S,3S,8R,9R)-10-((1S,3R,4S)-3,4-dihydroxy-cyclopentyl)-9-hydroxy-1-[(E)-(1S,2R)-2-methoxy-5-(4-methoxy-benzyloxy)-1,3-dimethyl-pent-3-enyl]-4,8-dimethyl-3-triisopropylsilanyloxy-deca-4,6-dienyl ester; With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 0.666667h;

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol049701h

Reference yield:

: 58794-19-7
3-allyl-hex-5-enal

: 691869-42-8
(Diethoxy-phosphoryl)-acetic acid (4E,6E)-(1S,3S,8R)-1-[(E)-(1S,2R)-2-methoxy-5-(4-methoxy-benzyloxy)-1,3-dimethyl-pent-3-enyl]-4-methyl-8-[(2R,4S)-6-oxo-4-(2-oxo-ethyl)-tetrahydro-pyran-2-yl]-3-triisopropylsilanyloxy-nona-4,6-dienyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: dibutylboron triflate; Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

1.2: 88 percent / Et₃N / CH₂Cl₂ / -78 - 0 °C

2.1: 85 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -78 - 0 °C

3.1: 91 percent / Grubb's catalyst / 1,2-dichloro-ethane / 0.33 h / 20 °C

4.1: 87 percent / 4-methylmorpholine N-oxide; OsO₄ / acetone; H₂O / 18 h / 20 °C

5.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.75 h / -78 - 0 °C

6.1: 58 percent / LiBH₄ / tetrahydrofuran; methanol / 24 h / 20 °C

7.1: 98 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

8.1: 97 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 16 h / 20 °C

9.1: LiHMDS / tetrahydrofuran / 0.67 h / -78 °C

9.2: 80 percent / tetrahydrofuran / -78 - 20 °C

10.1: 99 percent / DIBAl-H / CH₂Cl₂; hexane / 1.5 h / -78 °C

11.1: 90 percent / pyridine / tetrahydrofuran / 0.5 h / 0 - 20 °C

12.1: 88 percent / acetic acid / tetrahydrofuran; H₂O / 3 h / 20 °C

13.1: NaIO₄ / tetrahydrofuran; H₂O / 0.67 h / 20 °C

13.2: 75 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; acetone; 1.1: Evans aldol reaction / 1.2: Evans aldol reaction / 3.1: ring-closing metathesis / 7.1: Mitsunobu reaction;
DOI:10.1021/ol049701h