Adenosine, 2'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-(2-chlorophenyl phenylphosphoramidate), (R)-

Base Information

• Chemical Name: Adenosine, 2'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-(2-chlorophenyl phenylphosphoramidate), (R)-
• CAS No.: 69320-81-6
• Molecular Formula: C42H38ClN6O6P
• Molecular Weight: 789.227
• Mol file: 69320-81-6.mol

Synonyms:

Chemical Property of Adenosine, 2'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-(2-chlorophenyl phenylphosphoramidate), (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Adenosine, 2'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-(2-chlorophenyl phenylphosphoramidate), (R)-

There total 1 articles about Adenosine, 2'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 3'-(2-chlorophenyl phenylphosphoramidate), (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-chlorophenyl N-phenylphosphoramido chloridate (69320-80-5) + 2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]adenosine (51600-10-3) → C24H20Cl2N2O5P2 + C54H47Cl2N7O8P2 + 5'-O-monomethoxytrityl-2'-deoxyadenosine 3'-O-(2-chlorophenyl) phosphoranilidate (69320-81-6) + 5'-O-monomethoxytrityl-2'-deoxyadenosine 3'-O-(2-chlorophenyl) phosphoranilidate (69320-82-7)

Guidance literature:

In pyridine; for 18h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/0040-4020(84)85099-1

Reference yield: 91.0%

5'-O-monomethoxytrityl-2'-deoxyadenosine 3'-O-(2-chlorophenyl) phosphoranilidate (69320-81-6) → 2'-deoxyadenosine 3'-(2-chlorophenyl) phosphoranilidate (69320-83-8)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; chloroform; for 0.166667h; Ambient temperature;

DOI:10.1016/0040-4020(84)85099-1

Reference yield: 40.0%

5'-O-monomethoxytrityl-2'-deoxyadenosine 3'-O-(2-chlorophenyl) phosphoranilidate (69320-81-6) → 5'-O-monomethoxytrityl-2'-deoxyadenosine 3'-O-(2-chlorophenyl) phosphorothioate pyridinium salt

Guidance literature:

With carbon disulfide; sodium hydride; In N,N-dimethyl-formamide; 1.) r.t., 15 min; 2.) 30 min;

DOI:10.1016/0040-4020(84)85099-1

upstream raw materials:

o-chlorophenyl N-phenylphosphoramido chloridate

2'-deoxy-5-O-[(4-methoxyphenyl)(diphenyl)methyl]adenosine

Downstream raw materials:

2'-deoxyadenosine 3'-(2-chlorophenyl) phosphoranilidate

ammonium 2'-deoxyadenosine 3'-O-(2-chlorophenyl) phosphorothioate

(R_P)-2'-deoxyadenosine cyclic 3',5'-phosphoranilidate