2-Oxa-4,10,17-triazaoctadecan-18-oic acid, 9-(chloroacetyl)-12-[[(1,1-dimethylethoxy)carbonyl]amino]-3,11-dioxo-1- phenyl-, phenylmethyl ester

Base Information

• Chemical Name: 2-Oxa-4,10,17-triazaoctadecan-18-oic acid, 9-(chloroacetyl)-12-[[(1,1-dimethylethoxy)carbonyl]amino]-3,11-dioxo-1- phenyl-, phenylmethyl ester
• CAS No.: 693222-16-1
• Molecular Formula: C₃₄H₄₇ClN₄O₈
• Molecular Weight: 675.222
• Mol file: 693222-16-1.mol

Synonyms:

Chemical Property of 2-Oxa-4,10,17-triazaoctadecan-18-oic acid, 9-(chloroacetyl)-12-[[(1,1-dimethylethoxy)carbonyl]amino]-3,11-dioxo-1- phenyl-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Oxa-4,10,17-triazaoctadecan-18-oic acid, 9-(chloroacetyl)-12-[[(1,1-dimethylethoxy)carbonyl]amino]-3,11-dioxo-1- phenyl-, phenylmethyl ester

There total 4 articles about 2-Oxa-4,10,17-triazaoctadecan-18-oic acid, 9-(chloroacetyl)-12-[[(1,1-dimethylethoxy)carbonyl]amino]-3,11-dioxo-1- phenyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-tert-butoxycarbonylamino-7-chloro-6-oxo-heptyl)-carbamic acid benzyl ester (693222-12-7) → [5-(5-benzyloxycarbonylamino-1-chloroacetyl-pentylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester (693222-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HCl / dioxane

2.1: isobutyl chloroformate; Et₃N / tetrahydrofuran

2.2: Et₃N / tetrahydrofuran; dimethylformamide

With hydrogenchloride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm050377l

Reference yield:

6-(((benzyloxy)carbonyl)amino)-2-((tert butoxycarbonyl)amino)-hexanoic acid (2389-45-9,55878-47-2,52634-49-8) → [5-(5-benzyloxycarbonylamino-1-chloroacetyl-pentylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester (693222-16-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: isobutyl chloroformate; Et₃N / tetrahydrofuran / 0.17 h / -15 °C

1.2: diethyl ether / 12 h / 20 °C

2.1: HCl / dioxane / 0.25 h

3.1: HCl / dioxane

4.1: isobutyl chloroformate; Et₃N / tetrahydrofuran

4.2: Et₃N / tetrahydrofuran; dimethylformamide

With hydrogenchloride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm050377l

Reference yield:

((S)-5-tert-Butoxycarbonylamino-7-diazo-6-oxo-heptyl)-carbamic acid benzyl ester (172833-14-6) → [5-(5-benzyloxycarbonylamino-1-chloroacetyl-pentylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester (693222-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HCl / dioxane / 0.25 h

2.1: HCl / dioxane

3.1: isobutyl chloroformate; Et₃N / tetrahydrofuran

3.2: Et₃N / tetrahydrofuran; dimethylformamide

With hydrogenchloride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm050377l

upstream raw materials:

(5-amino-7-chloro-6-oxo-heptyl)-carbamic acid benzyl ester

6-(((benzyloxy)carbonyl)amino)-2-((tert butoxycarbonyl)amino)-hexanoic acid

(5-tert-butoxycarbonylamino-7-chloro-6-oxo-heptyl)-carbamic acid benzyl ester

((S)-5-tert-Butoxycarbonylamino-7-diazo-6-oxo-heptyl)-carbamic acid benzyl ester

Downstream raw materials:

C₆₅H₈₄N₈O₁₁

{4-[5-(4-benzyloxycarbonylamino-butyl)-3-methyl-6-oxo-1,6-dihydro-pyrazin-2-yl]-butyl}-carbamic acid benzyl ester