3-Quinolinecarboxylic acid, 6-[(2,3-dichlorophenyl)methyl]-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]-8-fluoro-1,4-dihydro-4-oxo-, ethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 6-[(2,3-dichlorophenyl)methyl]-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]-8-fluoro-1,4-dihydro-4-oxo-, ethyl ester
CAS No.:697762-24-6
Molecular Formula:C27H32Cl2FNO4Si
Molecular Weight:552.545
Hs Code.:

3-Quinolinecarboxylic acid,
6-[(2,3-dichlorophenyl)methyl]-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]
ethyl]-8-fluoro-1,4-dihydro-4-oxo-, ethyl ester

Synonyms:

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Chemical Property of 3-Quinolinecarboxylic acid, 6-[(2,3-dichlorophenyl)methyl]-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]-8-fluoro-1,4-dihydro-4-oxo-, ethyl ester

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Technology Process of 3-Quinolinecarboxylic acid, 6-[(2,3-dichlorophenyl)methyl]-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]-8-fluoro-1,4-dihydro-4-oxo-, ethyl ester

There total 1 articles about 3-Quinolinecarboxylic acid, 6-[(2,3-dichlorophenyl)methyl]-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]-8-fluoro-1,4-dihydro-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 697762-17-7
(2,3-dichlorobenzyl)zinc(II) chloride

: 697762-23-5
1-(2-tert-butyldimethylsilyloxyethyl)-8-fluoro-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 697762-24-6
1-(2-tert-butyldimethylsilyloxyethyl)-6-(2,3-dichlorobenzyl)-8-fluoro-4-oxo-1,4-3-carboxylic acid ethyl ester

Guidance literature:: trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 18h; Heating / reflux;

Reference yield: 100.0%

: 697762-24-6
1-(2-tert-butyldimethylsilyloxyethyl)-6-(2,3-dichlorobenzyl)-8-fluoro-4-oxo-1,4-3-carboxylic acid ethyl ester

: ethyl 6-(2,3-dichlorobenzyl)-1,4-dihydro-8-fluoro-1-(2-hydroxyethyl)-4-oxo-3-quinolinecarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 697762-24-6
1-(2-tert-butyldimethylsilyloxyethyl)-6-(2,3-dichlorobenzyl)-8-fluoro-4-oxo-1,4-3-carboxylic acid ethyl ester

: 6-(2,3-dichlorobenzyl)-8-fluoro-1-(2-hydroxyethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: 1-(2-tert-butyldimethylsilyloxyethyl)-6-(2,3-dichlorobenzyl)-8-fluoro-4-oxo-1,4-3-carboxylic acid ethyl ester; With ethanol; water; sodium hydroxide; for 1h; Reflux;

With acetic acid; In 20 °C;
DOI:10.1021/jm900460z