Chemical Property of 2-amino-2-(2H-tetrazol-5-yl)acetic acid
Chemical Property:
- Vapor Pressure:8.91E-09mmHg at 25°C
- Refractive Index:1.669
- Boiling Point:447.1 °C at 760 mmHg
- Flash Point:224.2 °C
- PSA：117.78000
- Density:1.804 g/cm3
- LogP:-1.01560
- Storage Temp.:Store at RT
- XLogP3:-4.1
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:143.04432442
- Heavy Atom Count:10
- Complexity:139
- Purity/Quality:
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97% *data from raw suppliers
(RS)-(Tetrazol-5-yl)glycine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1(=NNN=N1)C(C(=O)O)N
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Description
Tetrazolyl glycine is an NMDA receptor agonist. It binds to rat brain membranes with IC50 values of 98 and 36 nM for [3H]CGS19755 and [3H]glutamate, respectively, in radioligand binding assays. It induces depolarization in rat cortical slices, an effect that is blocked by the NMDA receptor antagonist LY233053. It induces degeneration of GABAergic and cholinergic neurons in the striatum of adult rats and the formation of excitotoxic lesions and seizures in neonatal rats (ED50 = 0.071 mg/kg). Intrastriatal injection of tetrazolyl glycine (5 μM) increases COX-2 expression in striatal neurons and the vasculature near the striatal injection site in a mouse model of excitotoxicity-induced neuronal injury.
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Uses
(RS)-(Tetrazol-5-yl)glycine is a highly potent NMDA receptor agonist demonstrating ~ 20X more activity than NMDA.
