6-Fluoro-1-methyl-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid

Base Information

Chemical Name:6-Fluoro-1-methyl-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid
CAS No.:70459-07-3
Molecular Formula:C15H16FN3O3
Molecular Weight:307.32000
Hs Code.:2933599550
UNII:QXW5GUD9BV
ChEMBL ID:CHEMBL284890
Nikkaji Number:J360.663E
Mol file:70459-07-3.mol

Synonyms:70459-07-3;QXW5GUD9BV;6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;Norfloxacin impurity K [EP IMPURITY];6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid;6-Fluoro-1-methyl-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-;UNII-QXW5GUD9BV;6-Fluoro-1-methyl-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid;CHEMBL284890;SCHEMBL11392814;A900260;6-fluoro-1-methyl-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid

Suppliers and Price of 6-Fluoro-1-methyl-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AvaChem
Desethylene ciprofloxacin
25mg
$ 425.00

AvaChem
Desethylene ciprofloxacin
10mg
$ 225.00

AvaChem
Desethylene ciprofloxacin
5mg
$ 125.00

Total 10 raw suppliers

Chemical Property of 6-Fluoro-1-methyl-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid

Chemical Property:

Boiling Point:551 oC
Flash Point:287 oC
PSA：72.88000
Density:1.388
LogP:1.02740
XLogP3:-1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:305.11756954
Heavy Atom Count:22
Complexity:504

Purity/Quality:

97% ^*data from raw suppliers

Desethylene ciprofloxacin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O

Technology Process of 6-Fluoro-1-methyl-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid

There total 7 articles about 6-Fluoro-1-methyl-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 110-85-0
piperazine

: 70032-16-5
7-chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

: 70459-07-3
desethyleneciprofloxacin

Guidance literature:: at 130 - 140 ℃; for 5h;
DOI:10.1021/jm00186a014

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 70459-07-3
desethyleneciprofloxacin

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 2 h / 120 - 130 °C

2: diphenyl ether / 1 h / Heating

3: K₂CO₃ / dimethylformamide / 10 h / 80 - 90 °C

4: 2N NaOH / 2 h / Heating

5: 40 percent / 5 h / 130 - 140 °C

With sodium hydroxide; potassium carbonate; In diphenylether; N,N-dimethyl-formamide;
DOI:10.1021/jm00186a014

Reference yield:

: 70032-30-3
diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate

: 70459-07-3
desethyleneciprofloxacin

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl ether / 1 h / Heating

2: K₂CO₃ / dimethylformamide / 10 h / 80 - 90 °C

3: 2N NaOH / 2 h / Heating

4: 40 percent / 5 h / 130 - 140 °C

With sodium hydroxide; potassium carbonate; In diphenylether; N,N-dimethyl-formamide;
DOI:10.1021/jm00186a014