1,3-Propanediol, 2-[[2-[[3-(dimethylamino)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl] propyl]amino]-6-fluoro-3-nitrophenyl]methyl]-, diacetate (ester)

Base Information

Chemical Name:1,3-Propanediol, 2-[[2-[[3-(dimethylamino)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl] propyl]amino]-6-fluoro-3-nitrophenyl]methyl]-, diacetate (ester)
CAS No.:705286-10-8
Molecular Formula:C26H44FN3O7Si
Molecular Weight:557.735
Hs Code.:

1,3-Propanediol,
2-[[2-[[3-(dimethylamino)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]
propyl]amino]-6-fluoro-3-nitrophenyl]methyl]-, diacetate (ester)

Synonyms:

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Chemical Property of 1,3-Propanediol, 2-[[2-[[3-(dimethylamino)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl] propyl]amino]-6-fluoro-3-nitrophenyl]methyl]-, diacetate (ester)

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

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Useful:

Technology Process of 1,3-Propanediol, 2-[[2-[[3-(dimethylamino)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl] propyl]amino]-6-fluoro-3-nitrophenyl]methyl]-, diacetate (ester)

There total 7 articles about 1,3-Propanediol, 2-[[2-[[3-(dimethylamino)-2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl] propyl]amino]-6-fluoro-3-nitrophenyl]methyl]-, diacetate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 705286-09-5
2-(tert-butyl-dimethyl-silanyloxymethyl)-N¹,N¹-dimethyl-propane-1,3-diamine

: 705286-03-9
acetic acid 2-acetoxymethyl-3-(2,6-difluoro-3-nitro-phenyl)-propyl ester

: 705286-10-8
acetic acid 2-acetoxymethyl-3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-dimethylaminomethyl-propylamino]-6-fluoro-3-nitro-phenyl}-propyl ester

Guidance literature:: With calcium carbonate; In dichloromethane; at 20 ℃; for 14h;
DOI:10.1021/jm050815o

Reference yield:

: 853245-97-3
2-hydroxymethyl-3-dimethylaminopropionitrile

: 705286-10-8
acetic acid 2-acetoxymethyl-3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-dimethylaminomethyl-propylamino]-6-fluoro-3-nitro-phenyl}-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LAH / tetrahydrofuran / 12 h / 20 °C

2: Et₃N; DMAP / CH₂Cl₂ / 14 h / 20 °C

3: CaCO₃ / CH₂Cl₂ / 14 h / 20 °C

With dmap; lithium aluminium tetrahydride; triethylamine; calcium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050815o

Reference yield:

: 251969-00-3
2-aminomethyl-3-dimethylamino-propan-1-ol

: 705286-10-8
acetic acid 2-acetoxymethyl-3-{2-[3-(tert-butyl-dimethyl-silanyloxy)-2-dimethylaminomethyl-propylamino]-6-fluoro-3-nitro-phenyl}-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; DMAP / CH₂Cl₂ / 14 h / 20 °C

2: CaCO₃ / CH₂Cl₂ / 14 h / 20 °C

With dmap; triethylamine; calcium carbonate; In dichloromethane;
DOI:10.1021/jm050815o