neplanocin D

Base Information

Chemical Name:neplanocin D
CAS No.:72877-47-5
Molecular Formula:C₁₁H₁₂N₄O₄
Molecular Weight:264.241
Hs Code.:
Mol file:72877-47-5.mol

Synonyms:6H-Purin-6-one,9-[4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-1,9-dihydro-, [1R-(1a,4b,5b)]-; Neplanocin D

Suppliers and Price of neplanocin D

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
NEPLANOCIN D 95.00%
5MG
$ 503.90

Total 3 raw suppliers

Chemical Property of neplanocin D

Chemical Property:

Vapor Pressure:1.37E-19mmHg at 25°C
Boiling Point:683°C at 760 mmHg
Flash Point:366.9°C
PSA：124.52000
Density:1.91g/cm³
LogP:-1.27290

Purity/Quality:

99% ^*data from raw suppliers

NEPLANOCIN D 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of neplanocin D

There total 7 articles about neplanocin D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 377748-86-2
(1'R,2'S,3'R)-9-[2,3-(isopropylidenedioxy)-4-(tert-butoxymethyl)-4-cyclopenten-1-yl]hypoxanthine

: 72877-47-5
(1'R,2'S,3'R)-9-[2,3-dihydroxy-4-hydroxymethyl-4-cyclopenten-1-yl]hypoxanthine

Guidance literature:: With trifluoroacetic acid; at 50 ℃; for 3h;
DOI:10.1021/jm010256v

Reference yield:

: 104010-72-2
(3aS,6aS)-2,2-dimethyl-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-one

: 72877-47-5
(1'R,2'S,3'R)-9-[2,3-dihydroxy-4-hydroxymethyl-4-cyclopenten-1-yl]hypoxanthine

Guidance literature:: Multi-step reaction with 7 steps

1.1: t-BuOK; sec-BuLi / hexane / 3.5 h / -70 °C

1.2: tetrahydrofuran; hexane / 3 h / -70 °C

2.1: DMAP; Et₃N / CH₂Cl₂ / 24 h / 20 °C

3.1: PdCl₂(CH₃CN)2; p-benzoquinone / tetrahydrofuran / 24 h / Heating

4.1: K₂CO₃ / methanol / 1 h / 20 °C

5.1: diethyl azadicarboxylate (DEAD); PPh₃ / tetrahydrofuran / 16 h / 20 °C

6.1: 2-mercaptoethanol; NaOMe / methanol / 24 h / Heating

7.1: aq. CF₃CO₂H / 3 h / 50 °C

With dmap; dichloro bis(acetonitrile) palladium(II); potassium tert-butylate; sec.-butyllithium; sodium methylate; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; 2-hydroxyethanethiol; p-benzoquinone; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm010256v

Reference yield:

: 377748-56-6
(1R,2S,3S)-1-(tert-butoxymethyl)-2,3-(isopropylidenedioxy)-4-cyclopenten-1-ol

: 72877-47-5
(1'R,2'S,3'R)-9-[2,3-dihydroxy-4-hydroxymethyl-4-cyclopenten-1-yl]hypoxanthine

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP; Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: PdCl₂(CH₃CN)2; p-benzoquinone / tetrahydrofuran / 24 h / Heating

3: K₂CO₃ / methanol / 1 h / 20 °C

4: diethyl azadicarboxylate (DEAD); PPh₃ / tetrahydrofuran / 16 h / 20 °C

5: 2-mercaptoethanol; NaOMe / methanol / 24 h / Heating

6: aq. CF₃CO₂H / 3 h / 50 °C

With dmap; dichloro bis(acetonitrile) palladium(II); sodium methylate; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; 2-hydroxyethanethiol; p-benzoquinone; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm010256v