Benzene, 2-[(ethenyloxy)methyl]-1,4-dimethoxy-

Base Information

• Chemical Name: Benzene, 2-[(ethenyloxy)methyl]-1,4-dimethoxy-
• CAS No.: 71255-03-3
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol file: 71255-03-3.mol

Synonyms:1,4-Dimethoxy-2-[(vinyloxy)methyl]benzene;Benzene,2-[(ethenyloxy)methyl]-1,4-dimethoxy;2,5-dimethoxybenzyl vinyl ether;

Chemical Property of Benzene, 2-[(ethenyloxy)methyl]-1,4-dimethoxy-

Chemical Property:

• Boiling Point: 288.2±30.0 °C(Predicted)
• PSA: 27.69000
• Density: 1.031±0.06 g/cm3(Predicted)
• LogP: 2.36390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 2-[(ethenyloxy)methyl]-1,4-dimethoxy-

There total 1 articles about Benzene, 2-[(ethenyloxy)methyl]-1,4-dimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,5-dimethoxybenzyl alcohol (33524-31-1) + ethyl vinyl ether (109-92-2,25104-37-4) → 2,5-dimethoxybenzyl vinyl ether (71255-03-3)

Guidance literature:

With mercury(II) diacetate; for 48h; Heating;

DOI:10.1021/jo00134a009

Reference yield: 30.0%

2,5-dimethoxybenzyl vinyl ether (71255-03-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3,6-Dimethoxy-2-vinyloxymethyl-benzaldehyde (87850-30-4)

Guidance literature:

With n-butyllithium; water; 1.) pentane, 0 deg C, 6 h; 2.) diethyl ether, 0 deg C, 12 h;

Reference yield:

2,5-dimethoxybenzyl vinyl ether (71255-03-3) → 2,5-dihydroxy-6-(3-methylbut-3-en-1-ynyl)benzaldehyde (63160-46-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) n-butyllithium, 2.) ethylene iodochloride / 1.) pentane, 0 deg C, 6 h, 2.) ether, from 0 deg C to 15 deg C, 2 h

2: 85 percent / Hg(OAc)2 / methanol / 0.5 h

3: 83 percent / pyridinium chlorochromate / acetone; CH₂Cl₂

4: 86 percent / BBr₃ / CH₂Cl₂ / 4 h / Ambient temperature

5: 5 mg / dimethylformamide / 3 h / 70 - 90 °C

With n-butyllithium; mercury(II) diacetate; boron tribromide; ethylene iodochloride; pyridinium chlorochromate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jo00134a009

upstream raw materials:

2,5-dimethoxybenzyl alcohol

ethyl vinyl ether

Downstream raw materials:

2-iodo-3,6-dimethoxybenzyl vinyl ether

3,6-Dimethoxy-2-vinyloxymethyl-benzaldehyde

2-hydroxymethyl-3-(3-methylbut-3-en-1-ynyl)benzene-1,4-diol

2,5-dihydroxy-6-(3-methylbut-3-en-1-ynyl)benzaldehyde