Invanz

Base Information

Chemical Name:Invanz
CAS No.:153773-82-1
Molecular Formula:C22H24N3NaO7S
Molecular Weight:497.504
Hs Code.:
European Community (EC) Number:836-232-1
NCI Thesaurus Code:C61753
RXCUI:353107
Mol file:153773-82-1.mol

Synonyms:ertapenem;ertapenem sodium;Invanoz;Invanz

Suppliers and Price of Invanz

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ErtapenemMonosodium(90%)
2.5g
$ 625.00

TRC
ErtapenemMonosodium(90%)
250mg
$ 105.00

DC Chemicals
ErtapenemSodium >99%
100 mg
$ 200.00

Crysdot
Ertapenemsodium 97%
5g
$ 614.00

Crysdot
Ertapenemsodium 97%
1g
$ 282.00

ChemScene
Ertapenemsodium 99.09%
100mg
$ 99.00

ChemScene
Ertapenemsodium 99.09%
1g
$ 328.00

ChemScene
Ertapenemsodium 99.09%
250mg
$ 130.00

Chemenu
sodium3-((2S,4S)-4-(((4R,5S,6S)-2-carboxy-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)pyrrolidine-2-carboxamido)benzoate 97%
5g
$ 580.00

Chemenu
sodium3-((2S,4S)-4-(((4R,5S,6S)-2-carboxy-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)pyrrolidine-2-carboxamido)benzoate 97%
1g
$ 267.00

Total 123 raw suppliers

Chemical Property of Invanz

Chemical Property:

Appearance/Colour:White or off-white powder
Vapor Pressure:5.26E-28mmHg at 25°C
Boiling Point:813.9 °C at 760 mmHg
Flash Point:446 °C
PSA：184.40000
LogP:-0.05430
Storage Temp.:-70°C
Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Water Solubility.:Fully miscible in water. Soluble in DMSO.
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:497.12326557
Heavy Atom Count:34
Complexity:882

Purity/Quality:

99% ^*data from raw suppliers

ErtapenemMonosodium(90%) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C2C(C(=O)N2C(=C1SC3CC([NH2+]C3)C(=O)NC4=CC=CC(=C4)C(=O)[O-])C(=O)[O-])C(C)O.[Na+]
Isomeric SMILES:C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H]([NH2+]C3)C(=O)NC4=CC=CC(=C4)C(=O)[O-])C(=O)[O-])[C@@H](C)O.[Na+]
Recent ClinicalTrials:Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)
Recent EU Clinical Trials:Short course antibiotic treatment of Gram-negative bacteremia: A multicenter, randomized, non-blinded, non-inferiority interventional study
Uses Ertapenem sodium has been used as a carbapenem in the NitroSpeed-Carba NP test in minimum inhibitory concentration (MIC) testing for differentiation of carbapenemases in Enterobacterales and Pseudomonas aeruginosa. It has also been used as an antibiotic to study its effects on the survival of septic mice.

Technology Process of Invanz

There total 3 articles about Invanz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.2%

: 202467-70-7
(4-nitrophenyl)methyl (4R,5S,6S)-3-[[(3S,5S)-5-[[(-carboxyphenyl)amino]carbonyl]-1-[[(4-nitrophenyl)methyoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

: 153773-82-1
[4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium

Guidance literature:: With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In water; ethyl acetate; for 2h; under 150015 - 225023 Torr; pH=7.1 - Ca. 7.2;

Reference yield:

: (4-nitrophenyl)methyl (4R,5S,6S)-3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate

: 153773-82-1
[4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium

Guidance literature:: (4-nitrophenyl)methyl (4R,5S,6S)-3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylate; With 4-methyl-morpholine; 2,6-dimethylpyridine; palladium 10% on activated carbon; hydrogen; In water; ethyl acetate; at 0 - 10 ℃; under 5250.53 - 7500.75 Torr;

With sodium hydrogencarbonate; In water; Reagent/catalyst;

Reference yield:

: 93711-81-0,90776-59-3,189188-38-3
(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

: 219909-83-8
(2S-cis)-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochloride

: 153773-82-1
[4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine / N,N-dimethyl-formamide / 3 h / -30 - -10 °C

2: 2,6-dimethylpyridine; hydrogen; 4-methyl-morpholine; palladium 10% on activated carbon / water; ethyl acetate / 0 - 10 °C / 5250.53 - 7500.75 Torr

With 4-methyl-morpholine; 2,6-dimethylpyridine; palladium 10% on activated carbon; hydrogen; diisopropylamine; In water; ethyl acetate; N,N-dimethyl-formamide;