2H-Pyran-2-one, 4-cyclohexyltetrahydro-, (R)-

Base Information

Chemical Name:2H-Pyran-2-one, 4-cyclohexyltetrahydro-, (R)-
CAS No.:71302-20-0
Molecular Formula:C11H18O2
Molecular Weight:182.263
Hs Code.:

Synonyms:

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Chemical Property of 2H-Pyran-2-one, 4-cyclohexyltetrahydro-, (R)-

Chemical Property:

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Technology Process of 2H-Pyran-2-one, 4-cyclohexyltetrahydro-, (R)-

There total 8 articles about 2H-Pyran-2-one, 4-cyclohexyltetrahydro-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607375-38-2
4-cyclohexyl-5,6-dihydropyran-2-one

: 71302-20-0,71796-69-5
4(R)-cyclohexyltetrahydropyran-2-one

: 71301-85-4,71796-69-5
4(S)-cyclohexyltetrahydropyran-2-one

Guidance literature:: With (+)-(S)-(6,6'-dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine); sodium t-butanolate; tert-Amyl alcohol; In toluene; pentane; at -40 ℃; for 6h; Title compound not separated from byproducts;
DOI:10.1021/ja0351692

Reference yield:

: 695-12-5,25498-06-0
vinylcyclohexane

: 71302-20-0,71796-69-5
4(R)-cyclohexyltetrahydropyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / ruthenium carbene / CH₂Cl₂ / 3 h / Heating

2.1: 55 percent / (CO)Ru(H)2(PPh₃)3 / toluene / 12 h / Heating

3.1: aq. H₂O₂; NaF; NaHCO₃ / methanol; tetrahydrofuran / 24 h

3.2: 90 percent / PPTS / 30 h / 115 °C

4.1: CuCl₂*H₂O; (S)-BIPHEMP; t-BuONa / PMHS; tert-amyl alcohol / toluene; pentane / 6 h / -40 °C

With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); ruthenium carbene; dihydrogen peroxide; sodium hydrogencarbonate; sodium fluoride; (+)-(S)-(6,6'-dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine); sodium t-butanolate; tert-Amyl alcohol; In tetrahydrofuran; methanol; dichloromethane; toluene; pentane;
DOI:10.1021/ja0351692

Reference yield:

: 17343-88-3
(E)-3-cyclohexyl-acrylic acid ethyl ester

: 71302-20-0,71796-69-5
4(R)-cyclohexyltetrahydropyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 55 percent / (CO)Ru(H)2(PPh₃)3 / toluene / 12 h / Heating

2.1: aq. H₂O₂; NaF; NaHCO₃ / methanol; tetrahydrofuran / 24 h

2.2: 90 percent / PPTS / 30 h / 115 °C

3.1: CuCl₂*H₂O; (S)-BIPHEMP; t-BuONa / PMHS; tert-amyl alcohol / toluene; pentane / 6 h / -40 °C

With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); dihydrogen peroxide; sodium hydrogencarbonate; sodium fluoride; (+)-(S)-(6,6'-dimethylbiphenyl-2,2'-diyl)bis(diphenylphosphine); sodium t-butanolate; tert-Amyl alcohol; In tetrahydrofuran; methanol; toluene; pentane;
DOI:10.1021/ja0351692