Benzoic acid, 2-hydroxy-4-[[(2-hydroxyphenyl)methylene]amino]-

Base Information

• Chemical Name: Benzoic acid, 2-hydroxy-4-[[(2-hydroxyphenyl)methylene]amino]-
• CAS No.: 71530-61-5
• Molecular Formula: C14H11NO4
• Molecular Weight: 257.24100
• Hs Code.: 2925290090
• European Community (EC) Number: 635-267-8
• DSSTox Substance ID: DTXSID80425419
• Nikkaji Number: J228.096E
• Mol file: 71530-61-5.mol

Synonyms:71530-61-5;Benzoic acid, 2-hydroxy-4-[[(2-hydroxyphenyl)methylene]amino]-;2-hydroxy-4-[(2-hydroxyphenyl)methylideneamino]benzoic acid;4-Salicylideneaminosalicylic acid;DTXSID80425419;AKOS024336522;4-[[(2-Hydroxyphenyl)methylene]amino]salicylic acid;2-{[(4-Carboxy-3-hydroxyphenyl)iminiumyl]methyl}phenolate;2-hydroxy-4-[(E)-(2-hydroxyphenyl)methyleneamino]benzoic acid;2-hydroxy-4-{[(E)-(2-hydroxyphenyl)methylidene]amino}benzoic acid;Benzoic acid, 2-hydroxy-4-[[(1E)-(2-hydroxyphenyl)methylene]amino]-

Chemical Property of Benzoic acid, 2-hydroxy-4-[[(2-hydroxyphenyl)methylene]amino]-

Chemical Property:

• PSA: 86.63000
• LogP: 2.15430
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 257.06880783
• Heavy Atom Count: 19
• Complexity: 344

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-HYDROXYBENZYLIDENEAMINO)SALICYLIC ACID Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=NC2=CC(=C(C=C2)C(=O)O)O)O

Technology Process of Benzoic acid, 2-hydroxy-4-[[(2-hydroxyphenyl)methylene]amino]-

There total 5 articles about Benzoic acid, 2-hydroxy-4-[[(2-hydroxyphenyl)methylene]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

salicylaldehyde (90-02-8) + 4-Aminosalicylic acid (65-49-6) → 2-hydroxy-4-[(2-hydroxybenzylidene)amino]benzoic acid (71530-61-5)

Guidance literature:

In methanol; at 20 ℃; for 1h;

DOI:10.1107/S0108270113018143

Reference yield:

2-methyl-benzyl alcohol (89-95-2) + 4-Aminosalicylic acid (65-49-6) → N-Salicylal-p-amino-salicylsaeure (71530-61-5)

Guidance literature:

In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2005.12.035

Reference yield:

→ 2-hydroxy-4-[(2-hydroxybenzylidene)amino]benzoic acid (71530-61-5)

Guidance literature:

With water; Ansaeuern des Reaktionsgemisches mit wss. HCl;

upstream raw materials:

2-methyl-benzyl alcohol

4-Aminosalicylic acid

salicylaldehyde