N-(4-Chlorophenyl)-1,3-propanesultam

Base Information

Chemical Name:N-(4-Chlorophenyl)-1,3-propanesultam
CAS No.:71703-13-4
Molecular Formula:C9H10ClNO2S
Molecular Weight:231.703
Hs Code.:
DSSTox Substance ID:DTXSID201231195

Synonyms:N-(4-CHLOROPHENYL)-1,3-PROPANESULTAM;71703-13-4;2-(4-chlorophenyl)-1,2-thiazolidine 1,1-dioxide;DTXSID201231195;WCA70313;BS-29412;Isothiazolidine, 2-(4-chlorophenyl)-, 1,1-dioxide;2-(4-CHLOROPHENYL)-1??,2-THIAZOLIDINE-1,1-DIONE

Suppliers and Price of N-(4-Chlorophenyl)-1,3-propanesultam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N-(4-Chlorophenyl)-1,3-propanesultam

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:231.0120774
Heavy Atom Count:14
Complexity:290

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(S(=O)(=O)C1)C2=CC=C(C=C2)Cl

Technology Process of N-(4-Chlorophenyl)-1,3-propanesultam

There total 1 articles about N-(4-Chlorophenyl)-1,3-propanesultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71703-13-4
N-(4-chlorophenyl)-1,2-isothiazolidine-1,1-dioxide

Guidance literature:: Sulfonsaeure (VIIIc), POCl3;

Reference yield:

: 71703-13-4
N-(4-chlorophenyl)-1,2-isothiazolidine-1,1-dioxide

: 151166-75-5
4-Methoxymethoxy-3,5-di-tert-butylbenzaldehyde

: 223579-49-5
[2-(4-chloro-phenyl)-1,1-dioxo-1λ⁶-isothiazolidin-5-yl]-(3,5-di-tert-butyl-4-methoxymethoxy-phenyl)-methanol

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1021/jm9906015

Reference yield:

: 71703-13-4
N-(4-chlorophenyl)-1,2-isothiazolidine-1,1-dioxide

: 2,6-di-tert-butyl-4-[2-(4-chloro-phenyl)-1,1-dioxo-1λ⁶-isothiazolidin-5-ylidenemethyl]-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine; BuLi; hexamethylphosphamide / hexane; tetrahydrofuran / 0.5 h / -78 °C

2: 39 percent / p-TsOH / toluene / 0.5 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; hexane; toluene; 1: Addition / 2: Dehydration;
DOI:10.1021/jm9906015