11,21-Dihydroxy-6-methylpregna-4,17-dien-3-one

Base Information

Chemical Name:11,21-Dihydroxy-6-methylpregna-4,17-dien-3-one
CAS No.:3386-04-7
Molecular Formula:C₂₂H₃₂O₃
Molecular Weight:344.494
Hs Code.:
European Community (EC) Number:222-204-0
DSSTox Substance ID:DTXSID40955449
Mol file:3386-04-7.mol

Synonyms:DTXSID40955449;3386-04-7;11,21-Dihydroxy-6-methylpregna-4,17-dien-3-one

Suppliers and Price of 11,21-Dihydroxy-6-methylpregna-4,17-dien-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 11,21-Dihydroxy-6-methylpregna-4,17-dien-3-one

Chemical Property:

Vapor Pressure:1.29E-12mmHg at 25°C
Boiling Point:511.8°Cat760mmHg
Flash Point:277.4°C
PSA：57.53000
Density:1.16g/cm³
LogP:3.65380
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:344.23514488
Heavy Atom Count:25
Complexity:648

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC(=CCO)C3(CC(C2C4(C1=CC(=O)CC4)C)O)C
Isomeric SMILES:C[C@H]1C[C@H]2[C@@H]3CCC(=CCO)[C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)CC4)C)O)C

Technology Process of 11,21-Dihydroxy-6-methylpregna-4,17-dien-3-one

There total 2 articles about 11,21-Dihydroxy-6-methylpregna-4,17-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3386-04-7,14423-17-7
11-Hydroxy-17-[2-hydroxy-eth-(E)-ylidene]-6,10,13-trimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

Guidance literature:: Enaminketon, Red.;

Reference yield:

: 1968-77-0
6-methyl-11-oxo-3-pyrrolidino-pregna-3,5,17⁽²⁰⁾c-trien-21-oic acid methyl ester

: 3386-04-7,14423-17-7
11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one

Guidance literature:: With lithium aluminium tetrahydride; diethyl ether; Behandeln des Reaktionsprodukts mit wss.-methanol.Alkalilauge;
DOI:10.1021/ja01604a078

Reference yield:

: 3386-04-7,14423-17-7
11β,21-dihydroxy-6α-methyl-pregna-4,17(20)c-dien-3-one

: 53-36-1,1048031-82-8
methylprednisolone acetate

Guidance literature:: Multi-step reaction with 2 steps

1: Dehydrierung durch Septomyxa affinis und anschliessende Acetylierung

2: diacetoxy-phenyl-iodan; OsO₄; tert-butyl alcohol / Reagens 4: Pyridin

With osmium(VIII) oxide; [bis(acetoxy)iodo]benzene; tert-butyl alcohol;
DOI:10.1021/ja01604a078