Adenosine, 2',3'-O-(ethoxymethylene)-, 5'-(2-chlorophenyl phenylphosphoramidate), (R)-

Base Information

Chemical Name:Adenosine, 2',3'-O-(ethoxymethylene)-, 5'-(2-chlorophenyl phenylphosphoramidate), (R)-
CAS No.:71960-50-4
Molecular Formula:C₂₅H₂₆ClN₆O₇P
Molecular Weight:588.944
Hs Code.:

Synonyms:

Suppliers and Price of Adenosine, 2',3'-O-(ethoxymethylene)-, 5'-(2-chlorophenyl phenylphosphoramidate), (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Adenosine, 2',3'-O-(ethoxymethylene)-, 5'-(2-chlorophenyl phenylphosphoramidate), (R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Adenosine, 2',3'-O-(ethoxymethylene)-, 5'-(2-chlorophenyl phenylphosphoramidate), (R)-

There total 1 articles about Adenosine, 2',3'-O-(ethoxymethylene)-, 5'-(2-chlorophenyl phenylphosphoramidate), (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 69320-80-5
o-chlorophenyl N-phenylphosphoramido chloridate

: 3250-02-0
2',3'-O-ethoxymethylidene adenosine

: 71960-50-4,71971-98-7
2',3'-ethoxymethylenadenosine 5'-

Guidance literature:: With 1,2,4-Triazole; In acetonitrile; for 96h;

Reference yield:

: 71960-50-4,71971-98-7
2',3'-ethoxymethylenadenosine 5'-

: 71971-96-5
N⁶,N⁶,O^2'-tribenzoyladenosine cyclic 3',5'-phosphoranilidate (S(P))

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 80percent acetic acid / 1.) water, room temp., 2 d; 2.) methanol, 24 h

2: 24 percent / potassium t-butoxide / dimethylsulfoxide / 72 h / Ambient temperature

3: 32 percent / pyridine / 2 h / Ambient temperature; 1.) 0 deg C

4: 1.) NaH; 2.) ⁽¹⁸⁾O-benzaldehyde, triethylamine / 1.) THF, 45 min, room temp., then 10 min, 35 deg C; 2.) 2 h, 30 deg C product containing ca. 86.5percent ⁽¹⁸⁾O-PO-

5: 70 percent / pyridine / 2 h / Ambient temperature

6: 24.9 percent / triphenylphosphine, carbon tetrachloride / acetonitrile / 12 h / Ambient temperature

With tetrachloromethane; [¹⁸O]-benzaldehyde; potassium tert-butylate; sodium hydride; acetic acid; triethylamine; triphenylphosphine; In pyridine; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 71960-50-4,71971-98-7
2',3'-ethoxymethylenadenosine 5'-

: 114218-40-5
N⁶,N⁶,O^2'-tribenzoyladenosine cyclic 3',5'-N,N-dimethylphosphoramidate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 80percent acetic acid / 1.) water, room temp., 2 d; 2.) methanol, 24 h

2: 24 percent / potassium t-butoxide / dimethylsulfoxide / 72 h / Ambient temperature

3: 32 percent / pyridine / 2 h / Ambient temperature; 1.) 0 deg C

4: 1.) NaH; 2.) ⁽¹⁸⁾O-benzaldehyde, triethylamine / 1.) THF, 45 min, room temp., then 10 min, 35 deg C; 2.) 2 h, 30 deg C product containing ca. 86.5percent ⁽¹⁸⁾O-PO-

5: 70 percent / pyridine / 2 h / Ambient temperature

6: 14.3 percent / PPh₃, CCl₄ / pyridine / 12 h / Ambient temperature

With tetrachloromethane; [¹⁸O]-benzaldehyde; potassium tert-butylate; sodium hydride; acetic acid; triethylamine; triphenylphosphine; In pyridine; dimethyl sulfoxide;