Aziridine, 2-ethylidene-1-(phenylmethyl)-, (2E)- (9CI)

Base Information

• Chemical Name: Aziridine, 2-ethylidene-1-(phenylmethyl)-, (2E)- (9CI)
• CAS No.: 721925-97-9
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• Mol file: 721925-97-9.mol

Synonyms:1-Benzyl-2-eth-(E)-ylidene-aziridine;(E)-N-benzyl-2-ethylideneaziridine;

Chemical Property of Aziridine, 2-ethylidene-1-(phenylmethyl)-, (2E)- (9CI)

Chemical Property:

• PSA: 3.01000
• LogP: 2.34390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Aziridine, 2-ethylidene-1-(phenylmethyl)-, (2E)- (9CI)

There total 3 articles about Aziridine, 2-ethylidene-1-(phenylmethyl)-, (2E)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(Z)-benzyl-(2-bromobut-2-enyl)amine → (E)-1-benzyl-2-ethylideneaziridine (721925-97-9)

Guidance literature:

With sodium amide; In ammonia; at -78 ℃; for 1h;

DOI:10.1021/ja0482684

Reference yield:

benzyl-(2-bromobut-2-enyl)amine → (Z)-1-benzyl-2-ethylideneaziridine (721925-98-0) + (E)-1-benzyl-2-ethylideneaziridine (721925-97-9)

Guidance literature:

With sodium amide; In ammonia; at -78 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/ja0482684

Reference yield:

benzylamine (100-46-9) → (E)-1-benzyl-2-ethylideneaziridine (721925-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N; MeSO₂Cl / tetrahydrofuran / 1.5 h / -30 - 0 °C

1.2: 92 percent / tetrahydrofuran / 18 h / Heating

2.1: 37 percent / NaNH₂ / liquid ammonia / 1 h / -78 °C

With sodium amide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; ammonia;

DOI:10.1021/ja0482684

upstream raw materials:

benzylamine

Refernces