6-(4-chloroanilino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

Base Information

• Chemical Name: 6-(4-chloroanilino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
• CAS No.: 7269-96-7
• Molecular Formula: C12H12ClN3O2
• Molecular Weight: 265.699
• Mol file: 7269-96-7.mol

Synonyms:1,3-Dimethyl-6-(4-chlor-anilin)-uracil;1,3-Dimethyl-6-(p-chloranilino)uracil;1,3-Dimethyl-4-[4-chlor-anilino]-uracil;

Chemical Property of 6-(4-chloroanilino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

Chemical Property:

• PSA: 56.03000
• LogP: 1.55400

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(4-chloroanilino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

There total 2 articles about 6-(4-chloroanilino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,3-Dimethyl-6-chlorouracil (6972-27-6) + 4-chloro-aniline (106-47-8) → 6-(4-chloro-anilino)-1,3-dimethyl-1H-pyrimidine-2,4-dione (7269-96-7)

Guidance literature:

In neat (no solvent); at 180 ℃; for 3h;

Reference yield:

→ 6-(4-chloro-anilino)-1,3-dimethyl-1H-pyrimidine-2,4-dione (7269-96-7)

Guidance literature:

1,3-Dimethyl-4-chlor-uracil, 4-Chloranilin, Butanol;

Reference yield: 92.0%

6-(4-chloro-anilino)-1,3-dimethyl-1H-pyrimidine-2,4-dione (7269-96-7) → 5-iodo-1,3-dimethyl-6-((4-chlorophenyl)amino)pyrimidine-2,4(1H,3H)-dione

Guidance literature:

With bis(acetylacetonate)oxovanadium; dihydrogen peroxide; acetic acid; potassium iodide; In ethanol; water; at 20 ℃; for 0.666667h;

DOI:10.1002/jhet.1575

upstream raw materials:

1,3-Dimethyl-6-chlorouracil

4-chloro-aniline

Downstream raw materials:

3-(4-chloro-phenyl)-4,6-dimethyl-3,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione

NCNMe₂