(3aR,6aR)-rel-hexahydro-Cyclopenta[b]pyrrol-2(1H)-one (Relative struc)

Base Information

• Chemical Name: (3aR,6aR)-rel-hexahydro-Cyclopenta[b]pyrrol-2(1H)-one (Relative struc)
• CAS No.: 72845-14-8
• Molecular Formula: C₇H₁₁NO
• Molecular Weight: 125.17
• Mol file: 72845-14-8.mol

Synonyms:Cyclopenta[b]pyrrol-2(1H)-one,hexahydro-,cis;

Chemical Property of (3aR,6aR)-rel-hexahydro-Cyclopenta[b]pyrrol-2(1H)-one (Relative struc)

Chemical Property:

• PSA: 32.59000
• LogP: 0.95090

Purity/Quality:

97% ^*data from raw suppliers

(3As,6aS)-Hexahydrocyclopenta[b]pyrrol-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3aR,6aR)-rel-hexahydro-Cyclopenta[b]pyrrol-2(1H)-one (Relative struc)

There total 8 articles about (3aR,6aR)-rel-hexahydro-Cyclopenta[b]pyrrol-2(1H)-one (Relative struc) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-[{3,5-bis(trifluoromethyl)benzoyl}oxy]-2-cyclopentylacetamide → 2-Oxo-cis-cyclopentanopyrrolidine (72845-14-8,214263-63-5)

Guidance literature:

With C₂₂H₂₆ClIrN₂O₃; potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In 2,2,2-trifluoroethanol; at 40 ℃; for 12h; diastereoselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.9b00791

Reference yield:

→ 2-Oxo-cis-cyclopentanopyrrolidine (72845-14-8,214263-63-5)

Guidance literature:

With ammonia; water; nickel; at 150 ℃; under 73550.8 - 80905.8 Torr; Hydrogenation;

Reference yield:

2-cyclopentylacetic acid (1123-00-8) → 2-Oxo-cis-cyclopentanopyrrolidine (72845-14-8,214263-63-5)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: potassium hydrogencarbonate / ethyl acetate; water / 12 h / 0 - 20 °C

3: potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; C₂₂H₂₆ClIrN₂O₃ / 2,2,2-trifluoroethanol / 12 h / 40 °C / Sealed tube

With oxalyl dichloride; C₂₂H₂₆ClIrN₂O₃; potassium carbonate; potassium hydrogencarbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; N,N-dimethyl-formamide; In dichloromethane; 2,2,2-trifluoroethanol; water; ethyl acetate;

DOI:10.1021/acs.orglett.9b00791

upstream raw materials:

cis-hexahydro-2H-cyclopenta[b]furan-2-one

(2-hydroxyiminocyclopentyl)acetic acid ethyl ester

2-cyclopentylacetic acid

2-cyclopentylacetyl chloride

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